CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; HTR7; HTR5A; HTR1F; ADRA1A; ADRB2; ADRB3; ADRA1D; ADRA2A; ADRA2B; DRD3; DRD2; HTR4; HTR1B; HTR1D; HTR1E; HTR2B; HTR2A; HTR1A; HTR2C; HTR6;
Peptide receptor (family A GPCR)	OPRD1; OPRM1;
Enzyme_unclassified	BLM; HSD17B10; MPO;
5HT3 receptor	HTR3A;
GABA-A receptor	GABRR1;
Lyase	CA12; CA7;
Plant homeodomain	KMT2A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
5HT3 receptor	HTR3A	Serotonin 3a (5-HT3a) receptor	P46098	CHEMBL1899
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	MPO	Myeloperoxidase	P05164	CHEMBL2439
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Peptide receptor (family A GPCR)	OPRM1	Mu opioid receptor	P35372	CHEMBL233

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	6.202E-12	2.597E-09	HTR1A, HTR1B, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	2.030E-09	6.226E-07	DRD2, DRD3, HTR1B, HTR2B
BP	GO:0008152; metabolic process	GO:0010513; positive regulation of phosphatidylinositol biosynthetic process	4.121E-08	9.753E-06	HTR2A, HTR2B, HTR2C
BP	GO:0009987; cellular process	GO:0014059; regulation of dopamine secretion	1.235E-07	2.611E-05	DRD2, DRD3, HTR1B, HTR2A
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	2.159E-07	4.123E-05	ADRA2A, DRD2, DRD3, OPRM1
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	7.577E-07	1.279E-04	ADRA1A, DRD2, HTR2A, HTR2B, HTR2C, OPRM1
BP	GO:0051179; localization	GO:0051209; release of sequestered calcium ion into cytosol	8.811E-07	1.432E-04	DRD2, HTR2A, HTR2B, HTR2C
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.041E-06	1.619E-04	CA7, DRD2, DRD3, HTR2A, HTR2B, HTR2C
BP	GO:0023052; signaling	GO:0051967; negative regulation of synaptic transmission, glutamatergic	1.485E-06	2.230E-04	DRD2, HTR1B, HTR2A
BP	GO:0009987; cellular process	GO:0007208; phospholipase C-activating serotonin receptor signaling pathway	2.659E-06	3.619E-04	HTR2A, HTR2C

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.323E-04	1.624E-03	CA12, CA7
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8.604E-39	3.786E-37	OPRD1, HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, ADRA1D, ADRB2, OPRM1, HTR2A, HTR5A, HTR4, ADRA2B, ADRA1A, ADRA2A, HTR6, GABRR1, HTR7, ADRB3, ADORA3, DRD2, DRD3
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	2.525E-15	3.703E-14	HTR6, HTR7, ADRB3, HTR2B, HTR2C, ADRA1D, ADRB2, HTR2A, HTR5A, HTR4, ADRA1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.835E-11	2.018E-10	HTR6, HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, ADRB2, HTR4, DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.771E-10	1.558E-09	OPRD1, ADRB3, ADORA3, ADRA1D, ADRB2, ADRA2B, ADRA1A, ADRA2A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	1.145E-05	6.587E-05	HTR2B, HTR2C, HTR2A, DRD2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	8.251E-22	1.815E-20	HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, HTR3A, HTR2A, HTR5A, HTR4, HTR6, HTR7
09150 Organismal Systems	09157 Sensory system	hsa04742	Taste transduction	3.534E-09	2.591E-08	HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, HTR3A
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	1.198E-05	6.587E-05	ADRB3, ADRA1D, ADRB2, ADRA1A
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5.104E-04	2.246E-03	HTR2B, HTR2C, HTR2A

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	ADRB3; HTR2B; HTR3A;
A00-B99: Certain infectious and parasitic diseases	Diarrhea	A09, K59.1	OPRM1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
A00-B99: Certain infectious and parasitic diseases	Infections disease	A00-B99	MPO;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
C00-D49: Neoplasms	Breast cancer	C50	DRD2;
C00-D49: Neoplasms	Prostate cancer	C61	ADRA1A;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	OPRM1; MPO; DRD2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Potentilla multifida

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities