CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; HCAR2; ADORA2A; ADORA1;
Enzyme_unclassified	TK1; ADK;
Lyase	CA2; CA14; CA12; CA9;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TK1	Thymidine kinase, cytosolic	P04183	CHEMBL2883
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226

Showing 1 to 10 of 10 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.868E-09	3.533E-05	CA12, CA14, CA2, CA9
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	8.380E-09	4.562E-05	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.070E-07	1.212E-03	CA12, CA2, CA9
BP	GO:0051179; localization	GO:0044070; regulation of anion transport	8.661E-06	9.933E-03	ADORA1, ADORA2A, CA2
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	7.235E-07	1.212E-03	ADORA1, ADORA2A
CC	GO:0044456; synapse part	GO:0099055; integral component of postsynaptic membrane	8.667E-06	9.933E-03	ADORA1, ADORA2A
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.930E-11	1.073E-06	CA12, CA14, CA2, CA9
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	3.493E-09	3.533E-05	ADORA1, ADORA2A, ADORA3

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.476E-11	1.645E-09	CA12, CA2, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.106E-04	1.217E-03	HCAR2, ADORA2A, ADORA1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.935E-04	2.152E-03	ADORA2A, ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.557E-03	8.562E-03	ADORA3, ADORA1

Showing 1 to 4 of 4 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
C00-D49: Neoplasms	Pancreatic cancer	C25	TK1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Prostate cancer	C61	TK1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	TK1; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	TK1; ADORA3; CA9;

Showing 1 to 10 of 60 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Pteris spinulosa

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities