CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; ALPL; RECQL; P4HB; HSD17B10; HPGD; ALDH1A1; AKR1B1;
Hydrolase	GAA;
Protein Kinase	FYN; EGFR;
Lyase	CA2; CA6; CA1;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205

Showing 1 to 10 of 15 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	2.669E-07	2.906E-03	AKR1B1, ALPL, CA2, EGFR, FYN, HPGD, NFKB1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.664E-06	1.160E-02	CA1, CA2, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.923E-06	1.531E-02	CA1, CA2, CA6
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	9.629E-06	1.760E-02	AKR1B1, ALPL, FYN, HPGD, NFKB1
BP	GO:0008283; cell proliferation	GO:0048661; positive regulation of smooth muscle cell proliferation	2.574E-05	4.004E-02	AKR1B1, EGFR, HPGD
CC	GO:0043226; organelle	GO:0031982; vesicle	9.256E-06	1.760E-02	AKR1B1, ALDH1A1, ALPL, CA1, CA2, CA6, EGFR, FYN, GAA, HPGD, P4HB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.714E-07	2.906E-03	CA1, CA2, CA6
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	6.983E-07	5.069E-03	AKR1B1, ALDH1A1, ALPL, CA1, CA2, CA6, EGFR, FYN, GAA, HPGD, HSD17B10, P4HB, RECQL, TDP1
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	8.428E-06	1.760E-02	CA1, CA2

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.306E-07	2.329E-05	CA1, CA2, CA6
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.256E-04	1.139E-02	GAA, AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.640E-03	3.019E-02	EGFR, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.375E-03	2.710E-02	FYN, EGFR
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	2.691E-03	3.019E-02	FYN, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.095E-03	2.710E-02	EGFR, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.162E-03	2.710E-02	EGFR, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.980E-03	2.857E-02	EGFR, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.548E-03	3.533E-02	FYN, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.610E-03	2.710E-02	GAA, ALDH1A1, AKR1B1, ALPL, HSD17B10

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Edema	NA	CA2;

Showing 1 to 10 of 11 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Phoebe clemensii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities