Plant ID: NPO6578
Plant Latin Name: Aglaia dasyclada
Taxonomy Genus: Aglaia
Taxonomy Family: Meliaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
577043-1
Unknown.
China
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | EIF4A1 | Eukaryotic initiation factor 4A-I | P60842 | CHEMBL2052028 |
Transcription Factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0050896; response to stimulus | GO:0033590; response to cobalamin | 3.106E-04 | 1.000E+00 | RELA |
BP | GO:0008152; metabolic process | GO:2000630; positive regulation of miRNA metabolic process | 5.177E-04 | 1.000E+00 | RELA |
BP | GO:0009987; cellular process | GO:0071316; cellular response to nicotine | 8.282E-04 | 1.000E+00 | RELA |
BP | GO:0009987; cellular process | GO:0071354; cellular response to interleukin-6 | 1.553E-03 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0010224; response to UV-B | 1.863E-03 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0035994; response to muscle stretch | 1.966E-03 | 1.000E+00 | RELA |
BP | GO:0008152; metabolic process | GO:0031293; membrane protein intracellular domain proteolysis | 1.966E-03 | 1.000E+00 | RELA |
BP | GO:0008152; metabolic process | GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter | 2.277E-03 | 1.000E+00 | RELA |
BP | GO:0009987; cellular process | GO:1901522; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | 2.897E-03 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0046627; negative regulation of insulin receptor signaling pathway | 3.104E-03 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0043278; response to morphine | 3.311E-03 | 1.000E+00 | RELA |
BP | GO:0009987; cellular process | GO:1901224; positive regulation of NIK/NF-kappaB signaling | 4.344E-03 | 1.000E+00 | RELA |
BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 6.306E-03 | 1.000E+00 | RELA |
BP | GO:0032501; multicellular organismal process | GO:0032481; positive regulation of type I interferon production | 7.441E-03 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0051591; response to cAMP | 9.916E-03 | 1.000E+00 | RELA |
BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 1.064E-02 | 1.000E+00 | RELA |
BP | GO:0032501; multicellular organismal process | GO:0001889; liver development | 1.084E-02 | 1.000E+00 | RELA |
BP | GO:0009987; cellular process | GO:0043620; regulation of DNA-templated transcription in response to stress | 1.218E-02 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0071222; cellular response to lipopolysaccharide | 1.228E-02 | 1.000E+00 | RELA |
BP | GO:0002376; immune system process | GO:0002223; stimulatory C-type lectin receptor signaling pathway | 1.270E-02 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 1.434E-02 | 1.000E+00 | RELA |
BP | GO:0065007; biological regulation | GO:0051092; positive regulation of NF-kappaB transcription factor activity | 1.444E-02 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0071375; cellular response to peptide hormone stimulus | 1.670E-02 | 1.000E+00 | RELA |
BP | GO:0032502; developmental process | GO:0007568; aging | 2.378E-02 | 1.000E+00 | RELA |
BP | GO:0050896; response to stimulus | GO:0050727; regulation of inflammatory response | 3.977E-02 | 1.000E+00 | RELA |
BP | GO:0032502; developmental process | GO:0009887; animal organ morphogenesis | 4.565E-02 | 1.000E+00 | RELA |
CC | GO:0032991; macromolecular complex | GO:0033256; I-kappaB/NF-kappaB complex | 7.247E-04 | 1.000E+00 | RELA |
CC | Unclassified; | GO:0043234; protein complex | 2.693E-02 | 1.000E+00 | EIF4A1, RELA |
CC | GO:0044464; cell part | GO:0005737; cytoplasm | 4.631E-02 | 1.000E+00 | EIF4A1, RELA |
MF | GO:0005488; binding | GO:0051059; NF-kappaB binding | 2.897E-03 | 1.000E+00 | RELA |
MF | GO:0140110; transcription regulator activity | GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | 3.001E-03 | 1.000E+00 | RELA |
MF | GO:0005488; binding | GO:0042805; actinin binding | 4.241E-03 | 1.000E+00 | RELA |
MF | GO:0005488; binding | GO:0070491; repressing transcription factor binding | 6.203E-03 | 1.000E+00 | RELA |
MF | GO:0005488; binding | GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding | 7.441E-03 | 1.000E+00 | RELA |
MF | GO:0005488; binding | GO:0042826; histone deacetylase binding | 1.115E-02 | 1.000E+00 | RELA |
MF | GO:0005488; binding | GO:0001046; core promoter sequence-specific DNA binding | 1.156E-02 | 1.000E+00 | RELA |
MF | GO:0140110; transcription regulator activity | GO:0001077; transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | 2.807E-02 | 1.000E+00 | RELA |
MF | GO:0005488; binding | GO:0000978; RNA polymerase II proximal promoter sequence-specific DNA binding | 4.038E-02 | 1.000E+00 | RELA |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 5.692E-03 | 1.944E-02 | RELA |
09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 6.490E-03 | 1.944E-02 | RELA |
09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 6.589E-03 | 1.944E-02 | RELA |
09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 5.692E-03 | 1.944E-02 | RELA |
09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 6.789E-03 | 1.944E-02 | RELA |
09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 7.486E-03 | 1.944E-02 | RELA |
09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 8.582E-03 | 1.944E-02 | RELA |
09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 9.975E-03 | 1.944E-02 | RELA |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 9.279E-03 | 1.944E-02 | RELA |
09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 1.037E-02 | 1.944E-02 | RELA |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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