CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	ADK; HSD17B10;
Lyase	CA2;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Metallo protease	MMP2; MMP9; MMP1;
Transcription Factor	NFKB1;
Methyl-lysine/arginine binding protein	L3MBTL1;
Unclassified	FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256

Showing 1 to 10 of 14 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	2.539E-08	2.765E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	1.140E-06	3.592E-03	ADORA1, ADORA2A, NFKB1, PPARA
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	1.463E-06	3.592E-03	ADORA1, ADORA2A
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	1.059E-08	2.306E-04	ADORA1, ADORA2A, ADORA3

Showing 1 to 4 of 4 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.726E-07	1.416E-05	ADORA2A, ADORA1, PPARA, NFKB1, TSHR
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.231E-05	6.623E-04	ADORA2A, ADORA3, ADORA1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	7.306E-05	1.198E-03	ADORA3, ADORA1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.392E-05	3.805E-04	FABP5, MMP1, PPARA
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6.858E-04	8.033E-03	ADORA1, TSHR
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.865E-06	1.175E-04	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.307E-04	1.787E-03	MMP1, MMP2, MMP9, NFKB1

Showing 1 to 7 of 7 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ADORA3; MMP9; MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;

Showing 1 to 10 of 62 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Scrophularia buergeriana

Taxonomic Information:

Plant External Links:

Used in Medicines:

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Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities