CMAUP Plant Collective Molecular Activities

Plant Name: Marrubium velutinum

Taxonomic Information:

Plant ID: NPO6536
Plant Latin Name: Marrubium velutinum
Taxonomy Genus: Marrubium
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Protein Kinase	CSNK2A1;
Lyase	CA2; CA12; CA7;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Enzyme_unclassified	HSD17B1; ACLY;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP3A4; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	ACLY	ATP-citrate synthase	P53396	CHEMBL3720
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.987E-12	6.350E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.075E-10	7.805E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	2.254E-08	4.463E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.626E-08	6.074E-05	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.904E-08	9.396E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.372E-07	1.757E-04	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.000E-07	4.839E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.322E-07	5.794E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	7.803E-07	7.388E-04	CYP19A1, CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.463E-06	1.138E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	1.463E-06	1.138E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.134E-06	1.408E-03	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.924E-06	1.721E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.924E-06	1.721E-03	CYP1A2, CYP3A4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.944E-06	2.147E-03	CA12, CA2, CA7
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	4.872E-06	2.588E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	7.305E-06	3.418E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	7.305E-06	3.418E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.022E-05	4.281E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.363E-05	5.494E-03	CYP1A1, CYP1A2
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.188E-05	8.214E-03	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.344E-12	4.570E-11	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.396E-08	5.773E-07	HSD17B1, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.590E-07	1.569E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.546E-07	1.731E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.657E-06	1.505E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.846E-07	1.569E-06	CA12, CA2, CA7
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.163E-05	5.646E-05	CYP1A2, CYP1A1, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.089E-04	4.628E-04	ACLY, HSD17B1, CYP1A2, CYP1A1, CYP3A4, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.039E-03	3.400E-03	CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.828E-04	6.904E-04	CYP1A2, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.100E-03	3.400E-03	CA2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.495E-03	9.904E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
NA: NA	Edema	NA	CA2;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE; CA2;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases