CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HCAR2;
Oxidoreductase	PTGS2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 3 of 3 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	8.583E-05	3.758E-01	LMNA, PTGS2
BP	GO:0051179; localization	GO:0032880; regulation of protein localization	1.516E-04	3.758E-01	HCAR2, LMNA, PTGS2
CC	GO:0016020; membrane	GO:0005901; caveola	1.099E-02	1.000E+00	PTGS2
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	3.106E-04	4.099E-01	PTGS2
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	4.659E-04	4.099E-01	PTGS2
MF	GO:0016209; antioxidant activity	GO:0004601; peroxidase activity	6.819E-03	9.457E-01	PTGS2
MF	GO:0005488; binding	GO:0020037; heme binding	1.975E-02	1.000E+00	PTGS2

Showing 1 to 7 of 7 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.272E-03	2.387E-02	PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	9.123E-03	2.387E-02	PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.641E-02	2.387E-02	PTGS2
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	7.482E-03	2.387E-02	PTGS2
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8.377E-03	2.387E-02	PTGS2
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.091E-02	2.387E-02	PTGS2
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.106E-02	2.387E-02	LMNA
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.285E-02	2.387E-02	PTGS2
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.344E-02	2.387E-02	LMNA
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.225E-02	2.387E-02	PTGS2

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	PTGS2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS2;
J00-J99: Diseases of the respiratory system	Asthma	J45	PTGS2;

Showing 1 to 10 of 25 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Myroxylon pereirae

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities