CMAUP Plant Collective Molecular Activities

Plant Name: Xylocarpus moluccensis

Taxonomic Information:

Plant ID: NPO6445
Plant Latin Name: Xylocarpus moluccensis
Taxonomy Genus: Xylocarpus
Taxonomy Family: Meliaceae

Plant External Links:

NCBI TaxonomyDB: 520510
Plant-of-the-World-Online: 579974-1

Used in Medicines:

Country/Region:

Thailand; Philippines

Traditional Medicine System:

Geographical Distribution:

Madagascar; Australia; Bangladesh; Myanmar; Thailand; Philippines; Cambodia; Seychelles; Mozambique; Somalia; Vietnam; Laos; Kenya; Fiji; Tanzania

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPA1;
Oxidoreductase	PTGS1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0050968; detection of chemical stimulus involved in sensory perception of pain	3.106E-04	1.000E+00	TRPA1
BP	GO:0032501; multicellular organismal process	GO:0050955; thermoception	3.106E-04	1.000E+00	TRPA1
BP	GO:0032501; multicellular organismal process	GO:0050966; detection of mechanical stimulus involved in sensory perception of pain	1.035E-03	1.000E+00	TRPA1
BP	GO:0008152; metabolic process	GO:0019371; cyclooxygenase pathway	1.139E-03	1.000E+00	PTGS1
BP	GO:0032501; multicellular organismal process	GO:0048265; response to pain	1.656E-03	1.000E+00	TRPA1
BP	GO:0051179; localization	GO:0051209; release of sequestered calcium ion into cytosol	4.654E-03	1.000E+00	TRPA1
BP	GO:0009987; cellular process	GO:0051289; protein homotetramerization	7.648E-03	1.000E+00	TRPA1
BP	GO:0050896; response to stimulus	GO:0042542; response to hydrogen peroxide	1.115E-02	1.000E+00	TRPA1
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.177E-02	1.000E+00	PTGS1
BP	GO:0065007; biological regulation	GO:0008217; regulation of blood pressure	1.537E-02	1.000E+00	PTGS1
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	2.142E-02	1.000E+00	TRPA1
BP	GO:0050896; response to stimulus	GO:0006954; inflammatory response	4.453E-02	1.000E+00	PTGS1
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	5.177E-04	1.000E+00	TRPA1
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	2.071E-04	1.000E+00	PTGS1
MF	GO:0005215; transporter activity	GO:0015278; calcium-release channel activity	1.863E-03	1.000E+00	TRPA1
MF	GO:0016209; antioxidant activity	GO:0004601; peroxidase activity	4.551E-03	1.000E+00	PTGS1
MF	GO:0003824; catalytic activity	GO:0051213; dioxygenase activity	9.297E-03	1.000E+00	PTGS1
MF	GO:0005488; binding	GO:0020037; heme binding	1.321E-02	1.000E+00	PTGS1
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	3.418E-02	1.000E+00	TRPA1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5.592E-03	1.460E-02	PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.191E-03	1.460E-02	PTGS1
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9.776E-03	1.460E-02	TRPA1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.117E-02	1.460E-02	PTGS1
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	1.216E-02	1.460E-02	PTGS1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.201E-01	1.201E-01	PTGS1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases