CMAUP Plant Collective Molecular Activities

Plant Name: Phlomis regelii

Taxonomic Information:

Plant ID: NPO6429
Plant Latin Name: Phlomis regelii
Taxonomy Genus: Phlomis
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1; PTPN2; ACP1; CDC25B; PTPRF;
Enzyme_unclassified	PLA2G1B; FAAH; RECQL; TERT; HSD11B1; AKR1B10; POLB;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Toll-like and Il-1 receptors	TLR2;
ATP-binding cassette	ABCB1;
Unclassified	LMNA; FABP3; FABP5; FABP2; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	5.382E-09	1.465E-05	NR1H4, PPARA, PPARD, PPARG, RORC
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	1.400E-08	2.909E-05	NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	3.200E-08	4.976E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.929E-07	2.000E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	4.079E-07	3.417E-04	NR1H4, PPARA, PPARD, PPARG, PTPN2
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	7.505E-07	5.636E-04	NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	1.046E-06	7.345E-04	FABP3, PLA2G1B, PPARA, PPARG, TLR2
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	2.093E-06	1.199E-03	NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	3.250E-06	1.608E-03	NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	3.805E-06	1.801E-03	FABP3, NR1H4, PPARG, TLR2
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	5.222E-06	2.317E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	5.222E-06	2.317E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.044E-05	3.787E-03	PTPN1, PTPN2
BP	GO:0065007; biological regulation	GO:0055088; lipid homeostasis	1.351E-05	4.598E-03	FABP3, FABP4, NR1H4, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	1.738E-05	5.822E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0045834; positive regulation of lipid metabolic process	2.100E-05	6.928E-03	FABP3, NR1H4, PPARA, PPARG
BP	GO:0009987; cellular process	GO:0071453; cellular response to oxygen levels	2.382E-05	7.366E-03	LMNA, PPARD, PPARG, TERT
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	2.605E-05	7.366E-03	PPARA, PPARG
BP	GO:0009987; cellular process	GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway	2.605E-05	7.366E-03	PPARG, PTPN2
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	2.605E-05	7.366E-03	PPARA, PPARG
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	2.605E-05	7.366E-03	FABP3, PPARG
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	2.975E-05	7.998E-03	FABP3, LMNA, PPARD, PPARG, PTPN2, TERT, TLR2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	3.828E-05	9.923E-03	NR1H4, PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	4.854E-05	1.161E-02	ACP1, PTPN2
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	2.329E-04	3.747E-02	CDC25B, FABP5, LMNA, NR1H4, POLB, PPARA, PPARD, PPARG, PTPN2, RECQL, RORC, TERT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.657E-12	1.913E-10	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.189E-04	4.281E-03	PTPN1, ACP1, PTPRF
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.737E-04	8.968E-03	PTPN1, PPARA, PTPRF
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	1.292E-03	2.325E-02	FABP2, PLA2G1B
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.397E-03	3.452E-02	FABP4, TSHR
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	3.214E-03	3.857E-02	RORC, TLR2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.822E-03	3.931E-02	ABCB1, NR1H4
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.397E-02	1.258E-01	PTPN1, PTPRF
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4.080E-02	1.832E-01	AKR1B10
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	4.205E-02	1.832E-01	POLB

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1;
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases