CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	HSD17B10; HPGD; ALDH1A1;
Transcription Factor	HIF1A;
Unclassified	GLI1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	GLI1	Zinc finger protein GLI1	P08151	CHEMBL5461

Showing 1 to 7 of 7 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.687E-06	1.195E-02	CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	2.362E-06	1.195E-02	CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	4.171E-06	1.195E-02	ALDH1A1, CYP1A2, CYP2D6, HPGD, HSD17B10
BP	GO:0008152; metabolic process	GO:0006690; icosanoid metabolic process	5.224E-06	1.195E-02	CYP1A2, CYP2D6, HPGD
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	4.065E-02	1.000E+00	CYP1A2, CYP2D6
MF	GO:0003824; catalytic activity	GO:0016491; oxidoreductase activity	1.499E-06	1.195E-02	ALDH1A1, CYP1A2, CYP2D6, HPGD, HSD17B10
MF	GO:0005488; binding	GO:0048037; cofactor binding	1.273E-05	1.834E-02	ALDH1A1, CYP1A2, CYP2D6, HPGD
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.838E-05	3.252E-02	CYP1A2, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.106E-04	1.147E-01	CYP1A2, CYP2D6
MF	GO:0005488; binding	GO:0051287; NAD binding	1.907E-04	1.560E-01	ALDH1A1, HPGD

Showing 1 to 10 of 11 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.161E-04	2.182E-03	CYP1A2, ALDH1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.436E-04	2.182E-03	CYP2D6, CYP1A2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.727E-04	2.182E-03	CYP2D6, CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.011E-02	3.465E-02	CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.013E-02	3.715E-02	CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.749E-03	1.049E-02	CYP1A2
09130 Environmental Information Processing	09132 Signal transduction	hsa04340	Hedgehog signaling pathway	1.737E-02	3.715E-02	GLI1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	7.726E-03	3.091E-02	GLI1, HIF1A
09160 Human Diseases	09161 Cancers	hsa05217	Basal cell carcinoma	1.909E-02	3.715E-02	GLI1
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.873E-03	3.091E-02	CYP1A2, ALDH1A1, HSD17B10

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Neolitsea sericea

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities