Plant Name: Neolitsea sericea
Taxonomic Information:
Plant ID: NPO6421
Plant Latin Name: Neolitsea sericea
Taxonomy Genus: Neolitsea
Taxonomy Family: Lauraceae
Plant External Links:
NCBI TaxonomyDB:
128655
Plant-of-the-World-Online:
467023-1
Used in Medicines:
Unknown.
Geographical Distribution:
Japan; South Africa
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HSD17B10; HPGD; ALDH1A1; | |
| HIF1A; | |
| GLI1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Unclassified | GLI1 | Zinc finger protein GLI1 | P08151 | CHEMBL5461 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.687E-06 | 1.195E-02 | CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 2.362E-06 | 1.195E-02 | CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 4.171E-06 | 1.195E-02 | ALDH1A1, CYP1A2, CYP2D6, HPGD, HSD17B10 |
| BP | GO:0008152; metabolic process | GO:0006690; icosanoid metabolic process | 5.224E-06 | 1.195E-02 | CYP1A2, CYP2D6, HPGD |
| MF | GO:0003824; catalytic activity | GO:0016491; oxidoreductase activity | 1.499E-06 | 1.195E-02 | ALDH1A1, CYP1A2, CYP2D6, HPGD, HSD17B10 |
| MF | GO:0005488; binding | GO:0048037; cofactor binding | 1.273E-05 | 1.834E-02 | ALDH1A1, CYP1A2, CYP2D6, HPGD |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 2.838E-05 | 3.252E-02 | CYP1A2, CYP2D6 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.106E-04 | 1.147E-01 | CYP1A2, CYP2D6 |
| MF | GO:0005488; binding | GO:0051287; NAD binding | 1.907E-04 | 1.560E-01 | ALDH1A1, HPGD |
| MF | GO:0005488; binding | GO:0097159; organic cyclic compound binding | 3.253E-04 | 2.133E-01 | ALDH1A1, CYP1A2, CYP2D6, GLI1, HIF1A, HPGD, HSD17B10 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 4.065E-02 | 1.000E+00 | CYP1A2, CYP2D6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.161E-04 | 2.182E-03 | CYP1A2, ALDH1A1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 2.436E-04 | 2.182E-03 | CYP2D6, CYP1A2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.727E-04 | 2.182E-03 | CYP2D6, CYP1A2 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 7.726E-03 | 3.091E-02 | GLI1, HIF1A |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 6.873E-03 | 3.091E-02 | CYP1A2, ALDH1A1, HSD17B10 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.011E-02 | 3.465E-02 | CYP1A2 |
| 09160 Human Diseases | 09161 Cancers | hsa05217 | Basal cell carcinoma | 1.909E-02 | 3.715E-02 | GLI1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04340 | Hedgehog signaling pathway | 1.737E-02 | 3.715E-02 | GLI1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.013E-02 | 3.715E-02 | CYP1A2 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 1.749E-03 | 1.049E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
