CMAUP Plant Collective Molecular Activities

Plant Name: Annona glabra

Taxonomic Information:

Plant ID: NPO6333
Plant Latin Name: Annona glabra
Taxonomy Genus: Annona
Taxonomy Family: Annonaceae

Plant External Links:

NCBI TaxonomyDB: 301703
Plant-of-the-World-Online: 72208-1

Used in Medicines:

Country/Region:

Netherlands; China

Traditional Medicine System:

TCM

Geographical Distribution:

Brazil; Guinea; Costa Rica; Bahamas; Suriname; Nigeria; Cameroon; Cote d'Ivoire; Ecuador; Cuba; El Salvador; Venezuela; Guatemala; China; Haiti; Belize; Sierra Leone; Liberia; Netherlands; Gambia; New Caledonia; United States; Trinidad and Tobago; Gabon; Guinea-Bissau; Guyana; Dominican Republic; Jamaica; Seychelles; Honduras; Mexico; Nicaragua; India; Senegal; Congo; Colombia; French Guiana; Fiji

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	RECQL; TDP1; AKR1B1; GFER; HSD17B10; ALDH1A1;
Lyase	CA2; CA12; CA9; CA7; CA5B; CA4;
Cysteine protease	CASP1; CASP7;
Transcription Factor	NFKB1;
Unclassified	LMNA; MCL1; MAPT; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2; CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.279E-15	2.020E-10	CA12, CA2, CA4, CA5B, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.551E-12	3.866E-08	CA12, CA2, CA4, CA5B, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.279E-11	9.281E-08	CA12, CA2, CA4, CA5B, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.936E-06	6.881E-03	CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	2.937E-06	6.881E-03	CA12, CA2, CA4, CA5B, CA7, CA9, CYP1A2, CYP1B1, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	8.048E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	6.589E-06	1.090E-02	AKR1B1, CA2, CA9, CYP1B1, LMNA, MAPT, MCL1, NFKB1, RECQL, TDP1
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	8.864E-06	1.090E-02	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.311E-05	2.097E-02	CYP1A2, CYP1B1, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.860E-14	1.543E-12	CA12, CA5B, CA2, CA4, CA7, CA9
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.192E-05	9.096E-04	CASP7, LMNA, NFKB1, MCL1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	3.823E-05	9.309E-04	CASP7, CASP1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.486E-05	9.309E-04	CYP1A2, CYP1B1, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.316E-05	1.048E-03	CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.936E-05	1.149E-03	CYP1A2, CYP1B1, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	9.687E-05	1.149E-03	CASP7, CASP1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.263E-04	1.311E-03	CYP1A2, CYP1B1, CYP3A4
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.035E-03	7.241E-03	CASP7, MAPT, HSD17B10
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.047E-03	7.241E-03	CYP1A2, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.493E-04	4.559E-03	CYP1A2, CYP3A4
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.438E-04	3.171E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases