CMAUP Plant Collective Molecular Activities

Plant Name: Croton caudatus

Taxonomic Information:

Plant ID: NPO6330
Plant Latin Name: Croton caudatus
Taxonomy Genus: Croton
Taxonomy Family: Euphorbiaceae

Plant External Links:

NCBI TaxonomyDB: 323037
Plant-of-the-World-Online: 342252-1

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk

Geographical Distribution:

Pakistan; Australia; Bangladesh; Myanmar; Philippines; Indonesia; India; Cambodia; Vietnam; China; Laos; Sri Lanka; Thailand; Nepal

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR35;
Enzyme_unclassified	RECQL; TDP1; HPGD; AKR1B1; APEX1; POLB;
Hydrolase	ACHE;
Protein Kinase	TEK; INSR; MET; EGFR; NUAK1; SRC; KDR; IGF1R; CSNK2A1;
Lyase	CA12;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
SLC superfamily of solute carriers	SLC22A6;
Unclassified	SMAD3; HSPA1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	TEK	Tyrosine-protein kinase TIE-2	Q02763	CHEMBL4128
Protein Kinase	INSR	Insulin receptor	P06213	CHEMBL1981
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	NUAK1	NUAK family SNF1-like kinase 1	O60285	CHEMBL5784
Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
SLC superfamily of solute carriers	SLC22A6	Solute carrier family 22 member 6	Q4U2R8	CHEMBL1641347
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267
Unclassified	SMAD3	Mothers against decapentaplegic homolog 3	P84022	CHEMBL1293258
Unclassified	HSPA1A	Heat shock 70 kDa protein 1	P0DMV8	CHEMBL5460

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0004714; transmembrane receptor protein tyrosine kinase activity	6.115E-11	1.331E-06	EGFR, IGF1R, INSR, KDR, MET, TEK
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	1.749E-09	3.462E-06	EGFR, IGF1R, INSR, KDR, SRC
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.116E-08	1.429E-05	AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, NR1H4, SMAD3, SRC, TEK
MF	Unclassified;	GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity	1.072E-07	5.695E-05	EGFR, INSR, KDR
MF	GO:0005488; binding	GO:0005524; ATP binding	1.613E-07	7.808E-05	CSNK2A1, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, RECQL, SRC, TEK
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	6.677E-07	2.019E-04	EGFR, INSR, MET, SRC, TEK
BP	GO:0009987; cellular process	GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway	8.968E-07	2.508E-04	EGFR, IGF1R, INSR, KDR, MET, SRC, TEK
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	1.238E-06	3.329E-04	APEX1, POLB
MF	Unclassified;	GO:0032403; protein complex binding	1.521E-06	3.989E-04	ACHE, APEX1, EGFR, IGF1R, INSR, KDR, SMAD3, SRC
BP	GO:0050896; response to stimulus	GO:1901653; cellular response to peptide	3.130E-06	7.100E-04	AKR1B1, APEX1, IGF1R, INSR, SRC
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	5.602E-06	1.081E-03	AKR1B1, CA12, EGFR, GPR35, INSR, MET, NR1H4, SMAD3
BP	GO:0050896; response to stimulus	GO:0034614; cellular response to reactive oxygen species	6.256E-06	1.174E-03	AKR1B1, APEX1, EGFR, SRC
BP	GO:0009987; cellular process	GO:0071363; cellular response to growth factor stimulus	6.957E-06	1.295E-03	EGFR, INSR, KDR, SMAD3, SRC
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	1.081E-05	1.913E-03	APEX1, CSNK2A1, EGFR, HPGD, SLC22A6, SRC, TEK
BP	GO:0008152; metabolic process	GO:0045429; positive regulation of nitric oxide biosynthetic process	1.329E-05	2.193E-03	EGFR, INSR, SMAD3
BP	GO:0009987; cellular process	GO:0035690; cellular response to drug	1.375E-05	2.230E-03	AKR1B1, APEX1, EGFR, KDR, SRC
BP	Unclassified;	GO:0006461; protein complex assembly	1.606E-05	2.498E-03	ACHE, HSPA1A, IGF1R, INSR, SLC22A6, SMAD3, SRC, TEK
BP	GO:0032501; multicellular organismal process	GO:0007435; salivary gland morphogenesis	2.591E-05	3.865E-03	EGFR, POLB
MF	Unclassified;	GO:0004872; receptor activity	2.627E-05	3.874E-03	EGFR, GPR35, HPGD, IGF1R, INSR, KDR, MET, NR1H4, TEK
BP	GO:0008152; metabolic process	GO:0045740; positive regulation of DNA replication	3.237E-05	4.638E-03	EGFR, IGF1R, INSR
MF	GO:0005488; binding	GO:0042802; identical protein binding	3.828E-05	5.310E-03	ACHE, CSNK2A1, EGFR, HPGD, IGF1R, KDR, MET, SLC22A6, SMAD3
CC	GO:0044464; cell part	GO:0048471; perinuclear region of cytoplasm	6.506E-05	8.049E-03	ACHE, AKR1B1, APEX1, EGFR, HSPA1A, SRC
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	6.647E-05	8.132E-03	EGFR, KDR, SRC, TEK
MF	GO:0005488; binding	GO:0043560; insulin receptor substrate binding	6.769E-05	8.143E-03	IGF1R, INSR
CC	GO:0016020; membrane	GO:0005901; caveola	6.970E-05	8.294E-03	INSR, SLC22A6, SRC
BP	GO:0051704; multi-organism process	GO:0035635; entry of bacterium into host cell	8.117E-05	9.401E-03	MET, SRC
BP	GO:0008283; cell proliferation	GO:0048661; positive regulation of smooth muscle cell proliferation	8.542E-05	9.789E-03	AKR1B1, EGFR, HPGD

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.158E-12	1.146E-10	SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.963E-09	9.719E-08	SRC, INSR, KDR, TEK, MET, EGFR, IGF1R
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	8.138E-09	2.685E-07	SMAD3, SRC, KDR, MET, EGFR, HSPA1A, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.283E-07	3.175E-06	INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.393E-06	2.758E-05	INSR, KDR, TEK, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.347E-06	3.319E-05	SRC, KDR, MET, EGFR, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	2.290E-06	3.319E-05	SRC, KDR, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	4.518E-06	5.592E-05	INSR, TEK, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	1.246E-05	1.370E-04	SMAD3, INSR, EGFR, IGF1R
09150 Organismal Systems	09149 Aging	hsa04213	Longevity regulating pathway - multiple species	4.608E-05	4.562E-04	INSR, HSPA1A, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5.527E-05	4.974E-04	SRC, MET, EGFR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	6.290E-05	5.189E-04	MET, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.692E-04	1.289E-03	SRC, EGFR, HSPA1A
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	8.425E-04	5.561E-03	SMAD3, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	9.734E-04	5.669E-03	HPGD, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.370E-03	7.537E-03	INSR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	9.228E-04	5.669E-03	SRC, EGFR
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	5.974E-04	4.224E-03	POLB, APEX1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; EGFR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Gastric cancer	C16	KDR; EGFR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Advanced breast cancer	C50	SRC;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; EGFR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	INSR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	INSR; AKR1B1;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR; TEK;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; IGF1R; KDR; TEK; EGFR; SRC;
K00-K95: Diseases of the digestive system	Crohn's disease	K50	INSR;
C00-D49: Neoplasms	Cancer	C00-C96	MET; IGF1R; KDR; CSNK2A1; ACHE; TEK; EGFR; SRC;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; EGFR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	TEK;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR; SRC;
C00-D49: Neoplasms	Breast cancer	C50	IGF1R; KDR; INSR; EGFR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR; AKR1B1;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	SRC;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperglycaemia in type 2 diabetes	E11, R73.9	INSR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	SRC;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	EGFR;
C00-D49: Neoplasms	Prostate cancer	C61	EGFR;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	INSR;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	TEK; SRC;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1/2 diabetes	E08-E13	INSR;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hunter syndrome	E76.1	INSR;
C00-D49: Neoplasms	Colon cancer	C50	EGFR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; EGFR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lymphoma	C81-C86	INSR; EGFR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; INSR;
C00-D49: Neoplasms	AML	NA	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	INSR;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
C00-D49: Neoplasms	Melanoma	C43	KDR; EGFR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; SRC;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypoglycemia	E16.0-E16.2	INSR;
C00-D49: Neoplasms	Osteosarcoma	C40-C41	SRC;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	SRC;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; SRC;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	IGF1R; ACHE; INSR;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases