CMAUP Plant Collective Molecular Activities

Plant Name: Angelica archangelica

Taxonomic Information:

Plant ID: NPO6190
Plant Latin Name: Angelica archangelica
Taxonomy Genus: Angelica
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 40949
Plant-of-the-World-Online: 837560-1

Used in Medicines:

Country/Region:

India; Romania; Finland; Lithuania; China

Traditional Medicine System:

Indian Folk; TCM; Ayurveda

Medicinal Functions:

Antispasmodic; Appetizer; Carminative; Diaphoretic; Diuretic; Expectorant; Stimulant; Stomachic; Tonic

Geographical Distribution:

Ukraine; Netherlands; Belarus; Lithuania; Denmark; Finland; India; Romania; France; United Kingdom; Sweden; Albania; China; Iceland; Belgium; Germany; Russia; Greenland; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ATP12A; GAA;
Protein Kinase	MAPK1;
Lyase	CA13; CA1; CA7; CA12; CA9;
Enzyme_unclassified	ALDH1A1; POLB;
Unclassified	MAPT; PAX8; NPC1; XPO1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2A13; CYP1A2; CYP2A6; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ATP12A	Potassium-transporting ATPase alpha chain 2	P54707	CHEMBL2933
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	XPO1	Exportin-1	O14980	CHEMBL5661
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.065E-12	4.497E-08	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.558E-10	1.392E-06	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.330E-10	3.192E-06	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.945E-09	1.346E-05	CYP1A2, CYP2A13, CYP2A6, CYP2C19
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.895E-08	4.126E-05	CYP1A2, CYP2C19, CYP2D6
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	3.314E-08	5.154E-05	CYP2A13, CYP2A6, CYP2D6
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.799E-08	5.170E-05	CYP2A13, CYP2A6, CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.212E-07	1.319E-04	CYP1A2, CYP2A13, CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0020037; heme binding	1.691E-07	1.753E-04	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.076E-07	1.965E-04	CYP1A2, CYP2A6, CYP2C19
MF	GO:0005488; binding	GO:0005506; iron ion binding	5.136E-07	4.142E-04	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	6.395E-07	4.802E-04	CYP2A13, CYP2A6, CYP2C19
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	1.019E-06	7.393E-04	CYP2A13, CYP2A6
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.659E-06	1.165E-03	CYP1A2, CYP2A13, CYP2D6
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.351E-06	2.871E-03	CYP1A2, CYP2A6, CYP2C19, CYP2D6, NPC1
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	5.183E-06	3.225E-03	CYP1A2, CYP2A13, CYP2C19, CYP2D6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.573E-12	3.930E-10	CA12, CA1, CA7, CA9, CA13
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.028E-07	2.776E-05	CYP2A6, CYP2D6, CYP1A2, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.570E-07	2.776E-05	CYP2A6, CYP2A13, CYP2D6, CYP1A2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.210E-06	3.326E-05	CYP2A6, CYP2A13, CYP1A2, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.590E-05	6.582E-04	CYP2A6, CYP1A2, ALDH1A1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.818E-04	2.857E-03	CYP2D6, MAPK1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	3.795E-04	4.639E-03	PAX8, MAPK1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.795E-04	4.639E-03	CYP1A2, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.417E-03	6.630E-02	CYP2A6, GAA, CYP1A2, ALDH1A1, CYP2C19
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	9.483E-06	2.086E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases