CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	RECQL; TDP1; ADK; GLO1; APEX1; POLB;
Hydrolase	ACHE;
Isomerase	TOP2A;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
SLC superfamily of solute carriers	SLCO1B1;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Isomerase	TOP2A	DNA topoisomerase II alpha	P11388	CHEMBL1806

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.256E-08	2.633E-04	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	1.072E-07	2.919E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.662E-07	4.022E-04	CA12, CA2, CA4, CA7
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	3.640E-07	7.927E-04	ADORA2A, CA2, CA7
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.024E-06	1.858E-03	ACHE, ADORA1, ADORA2A, CYP1A1, CYP1B1, NR1H4, SLCO1B1
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	1.238E-06	2.074E-03	APEX1, POLB
BP	GO:0050896; response to stimulus	GO:0006950; response to stress	3.198E-06	3.368E-03	ACHE, ADORA1, ADORA2A, ADORA3, APEX1, CA2, CYP1A1, CYP1B1, NR1H4, POLB, RECQL, TDP1, TOP2A
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	3.368E-03	CA2, CA7
BP	GO:0048511; rhythmic process	GO:0042752; regulation of circadian rhythm	4.248E-06	3.426E-03	ADORA1, ADORA2A, RORC, TOP2A
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.809E-06	2.462E-03	ADORA1, CA2, CA4, SLCO1B1, TSHR

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.588E-09	9.575E-08	CA12, CA2, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.784E-04	5.417E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.839E-03	6.806E-03	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.895E-03	9.739E-03	CYP1A1, CYP1B1
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	5.974E-04	4.421E-03	POLB, APEX1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.163E-04	2.666E-03	ADORA2A, ADORA3, ADORA1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.300E-03	6.338E-03	ADORA2A, ADORA1, TSHR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.290E-05	1.164E-03	SLCO1B1, CA2, NR1H4
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.882E-04	2.666E-03	CA2, CA4
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.370E-03	6.338E-03	CYP1A1, CYP1B1

Showing 1 to 10 of 11 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; ADORA3;
C00-D49: Neoplasms	Solid tumours	C00-D48	TOP2A;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Sequoia sempervirens

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities