CMAUP Plant Collective Molecular Activities

Plant Name: Sequoia sempervirens

Taxonomic Information:

Plant ID: NPO6187
Plant Latin Name: Sequoia sempervirens
Taxonomy Genus: Sequoia
Taxonomy Family: Cupressaceae

Plant External Links:

NCBI TaxonomyDB: 28980
Plant-of-the-World-Online: 263741-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Stimulant; Tonic

Geographical Distribution:

United States; Italy; China; Spain; France

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	RECQL; TDP1; ADK; GLO1; APEX1; POLB;
Hydrolase	ACHE;
Isomerase	TOP2A;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
SLC superfamily of solute carriers	SLCO1B1;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Isomerase	TOP2A	DNA topoisomerase II alpha	P11388	CHEMBL1806
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.708E-09	1.240E-05	CA12, CA2, CA4, CA7
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	4.475E-08	1.949E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.256E-08	2.633E-04	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	1.072E-07	2.919E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.662E-07	4.022E-04	CA12, CA2, CA4, CA7
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	3.640E-07	7.927E-04	ADORA2A, CA2, CA7
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.024E-06	1.858E-03	ACHE, ADORA1, ADORA2A, CYP1A1, CYP1B1, NR1H4, SLCO1B1
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	1.238E-06	2.074E-03	APEX1, POLB
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.799E-06	2.462E-03	CA12, CA2, CA4, CA7, GLO1, L3MBTL1, NR1H4, RORC
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.809E-06	2.462E-03	ADORA1, CA2, CA4, SLCO1B1, TSHR
BP	GO:0050896; response to stimulus	GO:0006950; response to stress	3.198E-06	3.368E-03	ACHE, ADORA1, ADORA2A, ADORA3, APEX1, CA2, CYP1A1, CYP1B1, NR1H4, POLB, RECQL, TDP1, TOP2A
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	3.368E-03	CA2, CA7
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	3.712E-06	3.368E-03	ADORA1, ADORA2A
BP	GO:0048511; rhythmic process	GO:0042752; regulation of circadian rhythm	4.248E-06	3.426E-03	ADORA1, ADORA2A, RORC, TOP2A

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.588E-09	9.575E-08	CA12, CA2, CA4, CA7
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.290E-05	1.164E-03	SLCO1B1, CA2, NR1H4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.163E-04	2.666E-03	ADORA2A, ADORA3, ADORA1, TSHR
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.784E-04	5.417E-03	CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.300E-03	6.338E-03	ADORA2A, ADORA1, TSHR
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.882E-04	2.666E-03	CA2, CA4
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.370E-03	6.338E-03	CYP1A1, CYP1B1
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	5.974E-04	4.421E-03	POLB, APEX1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.716E-03	6.806E-03	ADORA1, TSHR
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.839E-03	6.806E-03	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.895E-03	9.739E-03	CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; ADORA1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; ADORA2A; ADK;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; ADORA1; ADORA2A;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; ADORA3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA1; ADORA2A; ADORA3;
C00-D49: Neoplasms	Solid tumours	C00-D48	TOP2A;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
NA: NA	Upper abdominal bloating	NA	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE; ADK;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases