CMAUP Plant Collective Molecular Activities

Plant Name: Eupatorium riparium

Taxonomic Information:

Plant ID: NPO6147
Plant Latin Name: Eupatorium riparium
Taxonomy Genus: Eupatorium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia; China

Traditional Medicine System:

TCM

Geographical Distribution:

Indonesia; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	HTR6;
Enzyme_unclassified	TDP1; RECQL; MTOR;
Lyase	ODC1;
Oxidoreductase	MT-ND4;
Transcription Factor	TP53;
Unclassified	MAPT; PMP22; GMNN; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Lyase	ODC1	Ornithine decarboxylase	P11926	CHEMBL1869
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Oxidoreductase	MT-ND4	NADH-ubiquinone oxidoreductase chain 4	P03905	CHEMBL4499
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	PMP22	Peripheral myelin protein 22	Q01453	CHEMBL1293298
Unclassified	GMNN	Geminin	O75496	CHEMBL1293278
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.428E-06	1.835E-01	CYP2C19, CYP2D6
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	2.020E-05	1.861E-01	RECQL, TP53
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	2.677E-05	1.861E-01	MAPT, MTOR, TP53
BP	GO:0008152; metabolic process	GO:2000379; positive regulation of reactive oxygen species metabolic process	4.274E-05	1.861E-01	MAPT, MTOR, TP53
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	6.582E-05	2.389E-01	LMNA, MTOR, TP53
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	2.103E-04	3.570E-01	MAPT, TP53
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.113E-04	3.570E-01	CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.466E-04	3.570E-01	CYP2C19, CYP2D6
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	1.553E-03	5.046E-01	TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.078E-05	6.264E-03	HTR6, CYP2D6, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.212E-03	2.354E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.287E-03	2.354E-02	TP53, MTOR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.364E-03	2.354E-02	CYP2D6, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	2.256E-03	2.889E-02	TP53, MTOR
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	2.513E-03	2.889E-02	TP53, MTOR
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.924E-03	3.868E-02	TP53, MTOR
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	5.475E-03	4.722E-02	LMNA, TP53
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	8.152E-03	6.250E-02	SMN2, SMN1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.120E-02	7.027E-02	TP53, MTOR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	MTOR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	HTR6;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR6;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR6;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	HTR6;
NA: NA	Coronary artery restenosis	NA	MTOR;
C00-D49: Neoplasms	Solid tumors	NA	MTOR;
C00-D49: Neoplasms	Cancer	C00-C96	MTOR;
C00-D49: Neoplasms	Multiple myeloma	C90	MTOR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MTOR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MTOR;
C00-D49: Neoplasms	Bladder cancer	C67	MTOR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR6;
C00-D49: Neoplasms	Sarcoma	C81-C86	MTOR;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MTOR;
C00-D49: Neoplasms	Renal cancer	C64	MTOR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	MTOR;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MTOR;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Organ rejection	D89.8, T86	MTOR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR6;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Transplant rejection	D89.8, T86	MTOR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HTR6;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR6;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MTOR;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR;
C00-D49: Neoplasms	Advanced kidney cancer	C64	MTOR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases