CMAUP Plant Collective Molecular Activities

Plant Name: Ajania fastigiata

Taxonomic Information:

Plant ID: NPO6138
Plant Latin Name: Ajania fastigiata
Taxonomy Genus: Ajania
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 205360
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A13; CYP1A2; CYP2D6; CYP2A6; CYP3A4; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.052E-14	6.570E-10	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.603E-13	1.417E-09	CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	5.238E-13	2.281E-09	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.142E-12	3.551E-09	CYP1A2, CYP2A13, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.044E-12	4.945E-09	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.985E-12	5.909E-09	CYP1A2, CYP2A6, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.605E-11	6.541E-08	CYP1A2, CYP2A13, CYP2A6, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.332E-11	8.931E-08	CYP1A2, CYP2A13, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.364E-10	1.650E-07	CYP1A2, CYP2A13, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	1.019E-09	1.009E-06	CYP2A13, CYP2A6, CYP2D6
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	6.403E-09	5.577E-06	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	6.754E-09	5.656E-06	CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	1.977E-08	1.435E-05	CYP2A13, CYP2A6, CYP2C19
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	7.770E-08	4.834E-05	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	1.126E-07	6.625E-05	CYP2A13, CYP2A6
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	3.377E-07	1.793E-04	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.752E-07	3.267E-04	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.059E-06	2.203E-03	CYP1A2, CYP2C19
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.736E-05	1.875E-02	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
CC	Unclassified;	GO:0031143; pseudopodium	6.145E-03	9.697E-01	MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8.808E-12	5.766E-10	CYP2A6, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.177E-11	5.766E-10	CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.136E-11	6.978E-10	CYP2A6, CYP2A13, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.556E-08	2.341E-06	CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.136E-06	1.856E-05	CYP2A6, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.887E-06	8.241E-05	CYP2D6, MAPK1, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.079E-04	1.322E-03	CYP2A6, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.409E-04	4.321E-03	CYP2A6, CYP1A2, CYP2C19, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.720E-04	1.872E-03	CYP1A2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.050E-06	1.856E-05	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases