CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA7; CA4; CA12;
Unclassified	XPO1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Unclassified	XPO1	Exportin-1	O14980	CHEMBL5661

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.184E-07	1.290E-03	CA12, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.195E-07	1.593E-03	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	5.100E-04	5.047E-01	CYP1B1, CYP3A4
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.614E-03	1.000E+00	CA4, CYP1B1, CYP3A4, XPO1
CC	GO:0044464; cell part	GO:0005791; rough endoplasmic reticulum	1.482E-02	1.000E+00	CA4
CC	GO:0043226; organelle	GO:0015030; Cajal body	1.605E-02	1.000E+00	XPO1
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	4.958E-02	1.000E+00	XPO1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.567E-09	1.648E-04	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	2.973E-06	1.079E-02	CA12, CA4, CA7, CYP1B1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.028E-05	5.521E-02	CYP1B1, CYP3A4

Showing 1 to 10 of 11 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.019E-08	1.935E-07	CA12, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.231E-04	1.169E-03	CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.953E-04	1.171E-03	CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.194E-02	3.147E-02	CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.670E-03	2.745E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.372E-02	3.147E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.052E-02	3.343E-02	CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.491E-02	3.147E-02	CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6.881E-03	2.615E-02	CA4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.464E-04	1.171E-03	CYP1B1, CYP3A4

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Peucedanum ostruthium

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities