Plant ID: NPO6098
Plant Latin Name: Salvia officinalis
Taxonomy Genus: Salvia
Taxonomy Family: Lamiaceae
NCBI TaxonomyDB:
38868
Plant-of-the-World-Online:
n.a.
Antidiarrhoeal; Antihydrotic; Antiseptic; Antispasmodic; Appetizer; Aromatherapy; Astringent; Carminative; Cholagogue; Galactofuge; Stimulant; Tonic; Vasodilator
Italy; South Africa; India; China; Chile; Switzerland; Argentina; Spain
FFAR1; FFAR4; | |
TSHR; | |
TDP1; PKM; GFER; ALOX15; ALDH1A1; APEX1; POLB; | |
CA12; CA9; | |
PPARA; | |
THRB; | |
HIF1A; | |
ABCB1; | |
SLCO1B1; | |
FABP3; FABP4; LMNA; FABP5; |
Cytochrome P450 Enzymes: |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | PKM | Pyruvate kinase isozymes M1/M2 | P14618 | CHEMBL1075189 |
Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0005488; binding | GO:0005504; fatty acid binding | 1.782E-08 | 1.940E-04 | FABP3, FABP4, FABP5, FFAR4 |
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 1.126E-06 | 3.712E-03 | APEX1, POLB |
BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 2.508E-06 | 6.069E-03 | FABP3, FABP4, FABP5 |
BP | GO:0051179; localization | GO:0015711; organic anion transport | 4.081E-06 | 6.643E-03 | ABCB1, CA12, CA9, FABP3, PPARA, SLCO1B1 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 7.427E-07 | 3.120E-05 | FABP3, FABP4, FABP5, PPARA |
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.415E-04 | 2.971E-03 | CA12, CA9 |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 5.437E-04 | 7.611E-03 | POLB, APEX1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Ocular cancer | C69 | APEX1; |
C00-D49: Neoplasms | Refractory renal cell carcinoma | C64 | PKM; |
E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1; |
A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1; |
C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
E00-E89: Endocrine, nutritional and metabolic diseases | High cholesterol levels in blood | E78.0 | THRB; |
C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; PKM; ABCB1; CA9; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperthyroidism | E05 | THRB; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | THRB; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Wound healing | T14.0-T14.1 | THRB; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hypothyroidism | E03 | THRB; |
C00-D49: Neoplasms | Renal cancer | C64 | CA9; |
C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | ABCB1; |
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; ABCB1; CA9; |
C00-D49: Neoplasms | Ovarian cancer | C56 | ABCB1; |
C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ABCB1; |
C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PKM; |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; |
C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | THRB; |
I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A; |
C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; CA9; |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; |
C00-D49: Neoplasms | Breast cancer | C50 | CA9; |