Plant Name: Hymenodictyon excelsum
Taxonomic Information:
Plant ID: NPO6050
Plant Latin Name: Hymenodictyon excelsum
Taxonomy Genus: Hymenodictyon
Taxonomy Family: Rubiaceae
Plant External Links:
NCBI TaxonomyDB:
640128
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Thailand; Philippines; IndiaTraditional Medicine System:
Geographical Distribution:
Thailand; Philippines; India
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| BCL2; | |
| LIMK1; LCK; | |
| HPGD; ALDH1A1; HSD17B10; | |
| CASP7; CASP1; | |
| MCL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Protein Kinase | LIMK1 | LIM domain kinase 1 | P53667 | CHEMBL3836 |
| Protein Kinase | LCK | Tyrosine-protein kinase LCK | P06239 | CHEMBL258 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:2001244; positive regulation of intrinsic apoptotic signaling pathway | 1.915E-06 | 8.398E-03 | BCL2, LCK, MCL1 |
| MF | GO:0005488; binding | GO:0051434; BH3 domain binding | 1.928E-06 | 8.398E-03 | BCL2, MCL1 |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 6.081E-06 | 2.157E-02 | CASP1, CASP7, LCK |
| MF | GO:0003824; catalytic activity | GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis | 1.501E-05 | 3.225E-02 | CASP1, CASP7 |
| BP | GO:0009987; cellular process | GO:2000811; negative regulation of anoikis | 2.308E-05 | 3.425E-02 | BCL2, MCL1 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 1.081E-04 | 8.718E-02 | ALDH1A1, BCL2, CASP1, CASP7, HPGD, LCK, LIMK1, MCL1 |
| MF | GO:0005488; binding | GO:0051287; NAD binding | 3.257E-04 | 1.773E-01 | ALDH1A1, HPGD |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 4.012E-04 | 2.032E-01 | BCL2, CASP1, HPGD, LCK, MCL1 |
| CC | GO:0044464; cell part | GO:0005739; mitochondrion | 1.911E-03 | 3.801E-01 | BCL2, CASP1, HSD17B10, MCL1 |
| CC | GO:0032991; macromolecular complex | GO:0097136; Bcl-2 family protein complex | 2.793E-03 | 4.282E-01 | MCL1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.734E-05 | 1.176E-03 | CASP7, BCL2, MCL1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 2.269E-04 | 3.784E-03 | BCL2, CASP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.640E-04 | 3.784E-03 | CASP7, CASP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 4.911E-04 | 5.279E-03 | CASP7, CASP1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 7.539E-04 | 6.483E-03 | LCK, BCL2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 2.153E-03 | 1.492E-02 | BCL2, MCL1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.429E-03 | 1.492E-02 | CASP7, HSD17B10 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 9.640E-03 | 4.606E-02 | BCL2, MCL1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 7.385E-03 | 3.970E-02 | BCL2, MCL1 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05340 | Primary immunodeficiency | 1.653E-02 | 7.108E-02 | LCK |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | BCL2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | LCK; |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MCL1; BCL2; |
| C00-D49: Neoplasms | Breast cancer | C50 | BCL2; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2; |
| C00-D49: Neoplasms | Prostate cancer | C61 | BCL2; |
| C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
