CMAUP Plant Collective Molecular Activities

Plant Name: Globularia alypum

Taxonomic Information:

Plant ID: NPO5912
Plant Latin Name: Globularia alypum
Taxonomy Genus: Globularia
Taxonomy Family: Plantaginaceae

Plant External Links:

NCBI TaxonomyDB: 1533088
Plant-of-the-World-Online: 813050-1

Used in Medicines:

Country/Region:

Turkey; Algeria

Traditional Medicine System:

Geographical Distribution:

Turkey; Albania; Italy; Libya; Algeria; Egypt; France; Morocco; Tunisia; Greece; Spain

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	PRKCA;
Metallo protease	MMP12; MMP2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	3.338E-05	2.127E-01	MMP12, MMP2
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	4.942E-05	2.127E-01	MMP12, MMP2
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	5.861E-05	2.127E-01	MMP12, MMP2
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	8.917E-05	2.287E-01	MMP12, MMP2
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	9.652E-05	2.287E-01	MMP12, MMP2, PRKCA
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.430E-05	2.287E-01	MMP12, MMP2, PRKCA
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	1.050E-04	2.287E-01	MMP12, MMP2
BP	GO:0002376; immune system process	GO:0002684; positive regulation of immune system process	1.430E-04	2.595E-01	MMP12, MMP2, PRKCA
MF	GO:0003824; catalytic activity	GO:0035403; histone kinase activity (H3-T6 specific)	3.106E-04	3.757E-01	PRKCA
CC	GO:0044421; extracellular region part	GO:0005578; proteinaceous extracellular matrix	6.221E-04	4.772E-01	MMP12, MMP2
MF	GO:0003824; catalytic activity	GO:0004252; serine-type endopeptidase activity	4.884E-04	4.772E-01	MMP12, MMP2
MF	GO:0003824; catalytic activity	GO:0004698; calcium-dependent protein kinase C activity	6.212E-04	4.772E-01	PRKCA
CC	GO:0044464; cell part	GO:0005739; mitochondrion	1.281E-02	1.000E+00	MMP2, PRKCA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7.550E-05	2.097E-03	MMP2, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	6.125E-05	2.097E-03	MMP2, PRKCA
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	3.055E-04	4.659E-03	MMP2, PRKCA
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	1.031E-04	2.097E-03	MMP2, PRKCA
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.164E-03	1.420E-02	MMP2, PRKCA
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	1.002E-02	2.404E-02	PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	9.868E-03	2.404E-02	PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04911	Insulin secretion	1.270E-02	2.404E-02	PRKCA
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	1.433E-02	2.404E-02	PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.507E-02	2.404E-02	PRKCA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases