Plant Name: Etlingera elatior
Taxonomic Information:
Plant ID: NPO5878
Plant Latin Name: Etlingera elatior
Taxonomy Genus: Elettaria
Taxonomy Family: Zingiberaceae
Plant External Links:
NCBI TaxonomyDB:
188493
Plant-of-the-World-Online:
942355-1
Used in Medicines:
Country/Region:
IndiaTraditional Medicine System:
Indian Folk; Unani; Ayurveda; SiddhaGeographical Distribution:
Australia; Honduras; Philippines; Indonesia; India; Costa Rica; Mauritius; Trinidad and Tobago; China; Thailand; Dominican Republic
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| DRD3; HTR2C; | |
| OPRD1; | |
| PTPN1; | |
| KCNA3; | |
| AKR1B10; AKR1B1; | |
| BACE1; | |
| VCP; | |
| MCL1; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Endoplasmic reticular retrotranslocon family | VCP | Transitional endoplasmic reticulum ATPase | P55072 | CHEMBL1075145 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Potassium channels | KCNA3 | Voltage-gated potassium channel subunit Kv1.3 | P22001 | CHEMBL4633 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Small molecule receptor (family A GPCR) | DRD3 | Dopamine D3 receptor | P35462 | CHEMBL234 |
| Small molecule receptor (family A GPCR) | HTR2C | Serotonin 2c (5-HT2c) receptor | P28335 | CHEMBL225 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0044597; daunorubicin metabolic process | 9.886E-06 | 5.507E-02 | AKR1B1, AKR1B10 |
| BP | GO:0008152; metabolic process | GO:0044598; doxorubicin metabolic process | 9.886E-06 | 5.507E-02 | AKR1B1, AKR1B10 |
| BP | GO:0008152; metabolic process | GO:0017144; drug metabolic process | 1.012E-05 | 5.507E-02 | AKR1B1, AKR1B10, CYP3A4, DRD3, VCP |
| MF | GO:0003824; catalytic activity | GO:0004033; aldo-keto reductase (NADP) activity | 1.140E-04 | 3.104E-01 | AKR1B1, AKR1B10 |
| BP | GO:0007610; behavior | GO:0007626; locomotory behavior | 1.619E-04 | 3.366E-01 | DRD3, HTR2C, OPRD1 |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 6.867E-04 | 3.606E-01 | BACE1, KCNA3, OPRD1 |
| CC | GO:0044464; cell part | GO:0042995; cell projection | 9.821E-04 | 3.606E-01 | AKR1B1, BACE1, DRD3, KCNA3, OPRD1 |
| MF | GO:0005488; binding | GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding | 1.242E-03 | 3.606E-01 | HTR2C |
| CC | GO:0043226; organelle | GO:0031982; vesicle | 3.284E-03 | 5.003E-01 | AKR1B1, AKR1B10, BACE1, DRD3, OPRD1, PTPN1, VCP |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 3.722E-03 | 5.003E-01 | PTPN1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 2.427E-04 | 2.588E-03 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.679E-04 | 2.588E-03 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.913E-04 | 2.588E-03 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 6.535E-04 | 4.340E-03 | AKR1B10, AKR1B1 |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 6.782E-04 | 4.340E-03 | OPRD1, HTR2C, DRD3 |
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 5.389E-03 | 2.874E-02 | SMN2, SMN1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 4.251E-02 | 9.412E-02 | AKR1B10, AKR1B1, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00983 | Drug metabolism - other enzymes | 2.950E-02 | 9.412E-02 | CYP3A4 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.869E-02 | 8.545E-02 | CYP3A4 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 4.145E-02 | 9.412E-02 | CYP3A4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Premature ejaculation | F52.4 | OPRD1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | OPRD1; |
| N00-N99: Diseases of the genitourinary system | Bladder disease | N30-N32 | OPRD1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | OPRD1; |
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | OPRD1; |
| G00-G99: Diseases of the nervous system G00-G99 | Acute migraine | G43 | OPRD1; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cough | R05 | OPRD1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | OPRD1; |
| K00-K95: Diseases of the digestive system | Diarrhea-predominant IBS | K58.0 | OPRD1; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | KCNA3; |
| I00-I99: Diseases of the circulatory system | Ischemic heart diseases | I20-I25 | OPRD1; |
| NA: NA | Chronic diarrhea associated with inflammatory bowel disease | NA | OPRD1; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | OPRD1; |
| N00-N99: Diseases of the genitourinary system | Urinary incontinence | N39.3, N39.4, R32 | OPRD1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | OPRD1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic arthritis | L40.5, M07 | KCNA3; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Moderate-to-severe pain | R52, G89 | OPRD1; |
| NA: NA | Acute nonspecific diarrhea | NA | OPRD1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
