CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALOX15;
Cysteine protease	CASP1; CASP7;
Transcription Factor	HIF1A;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	7.329E-07	1.596E-02	CASP1, CASP7, XDH
BP	GO:0009987; cellular process	GO:0097194; execution phase of apoptosis	3.755E-05	8.175E-02	CASP1, CASP7
BP	GO:0032502; developmental process	GO:0007595; lactation	4.378E-05	8.666E-02	HIF1A, XDH
BP	GO:0009987; cellular process	GO:0001961; positive regulation of cytokine-mediated signaling pathway	4.820E-05	8.747E-02	CASP1, HIF1A
CC	GO:0044464; cell part	GO:0005829; cytosol	9.852E-04	2.591E-01	ALOX15, CASP1, CASP7, HIF1A, XDH
MF	GO:0003824; catalytic activity	GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis	4.177E-06	2.206E-02	CASP1, CASP7
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.177E-04	2.011E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	7.764E-04	2.285E-01	ALOX15

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.230E-03	3.744E-02	ALOX15
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.541E-02	3.744E-02	ALOX15
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.250E-03	1.125E-02	XDH
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.417E-02	3.744E-02	CASP1
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	1.590E-02	3.744E-02	CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	7.386E-05	1.860E-03	CASP7, CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.377E-04	1.860E-03	CASP7, CASP1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.269E-02	3.744E-02	CASP1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.639E-02	3.744E-02	HIF1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.664E-02	3.744E-02	HIF1A

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Koelpinia linearis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities