CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Hydrolase	ACHE;
Enzyme_unclassified	RECQL; ALOX12; HSD17B1; HSD17B10; NOX4; POLB;
Miscellaneous ion channel	BCL2;
Protein Kinase	PIM1; MET; AXL; FLT3; CDK1; KDR; IGF1R; AURKB; CSNK2A1;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Metallo protease	MMP12;
Transcription Factor	HIF1A;
Unclassified	ITGAL; LMNA; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236

Showing 1 to 10 of 33 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	1.375E-07	1.302E-04	ALOX12, BCL2, CDK1, CSNK2A1, FLT3, HIF1A, IGF1R, KDR, MMP12, PIM1, THPO
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.407E-07	3.679E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	8.914E-07	4.961E-04	AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.917E-06	1.789E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	7.860E-06	2.257E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	7.997E-06	2.261E-03	ALOX12, BCL2, HIF1A, IGF1R, KDR, MET, NOX4
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	8.303E-06	2.318E-03	AXL, CDK1, CSNK2A1, FLT3
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	8.482E-06	2.338E-03	BCL2, NR1H4
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.496E-05	3.393E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.695E-05	3.690E-03	CYP1A1, CYP1A2

Showing 1 to 10 of 24 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.835E-08	1.822E-06	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.879E-05	9.212E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.739E-06	8.675E-05	CA12, CA4, CA7
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.353E-04	2.891E-03	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	3.876E-04	3.068E-03	KDR, ITGAL, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	6.468E-04	4.389E-03	BCL2, HIF1A, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9.112E-04	5.771E-03	THPO, FLT3, KDR, MET
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.449E-04	2.891E-03	CSNK2A1, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	3.286E-04	2.891E-03	KDR, BCL2, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.790E-08	1.701E-06	HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R

Showing 1 to 10 of 16 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3; ITGAL;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; BCL2;

Showing 1 to 10 of 106 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Rumex nepalensis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities