CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Enzyme_unclassified	TDP1; AKR1B10; AKR1B1; HSD17B10;
Lyase	CA2; CA1; CA12; CA9; CA5B; CA5A; CA3; CA14; CA7; CA6;
Methyl-lysine/arginine binding protein	KDM4A; KDM4C; L3MBTL1;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	NFKB1;
Unclassified	LMNA; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789

Showing 1 to 10 of 24 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	6.036E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.394E-21	2.606E-17	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.173E-19	6.386E-16	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:1900113; negative regulation of histone H3-K9 trimethylation	1.476E-05	1.692E-02	KDM4A, KDM4C
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	4.124E-05	3.454E-02	AKR1B1, AKR1B10
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.953E-27	6.430E-23	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.507E-17	1.635E-13	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, KDM4A, KDM4C, L3MBTL1, MMP1, MMP2, MMP9, PTPN1
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	2.294E-02	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0051864; histone demethylase activity (H3-K36 specific)	6.618E-05	4.503E-02	KDM4A, KDM4C

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.349E-26	1.052E-24	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	8.480E-04	1.323E-02	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.881E-04	1.306E-02	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6.696E-04	1.306E-02	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	2.265E-03	2.524E-02	AKR1B10, AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	7.645E-03	5.421E-02	MMP9, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	6.236E-03	5.421E-02	MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.571E-05	6.126E-04	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.186E-03	1.542E-02	MMP1, MMP2, MMP9, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6.482E-03	5.421E-02	MMP2, NFKB1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; MMP9; MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;

Showing 1 to 10 of 23 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Psorothamnus spinosus

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities