CMAUP Plant Collective Molecular Activities

Plant Name: Silybum marianum

Taxonomic Information:

Plant ID: NPO5645
Plant Latin Name: Silybum marianum
Taxonomy Genus: Silybum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 92921
Plant-of-the-World-Online: 249211-1

Used in Medicines:

Country/Region:

Pakistan; Israel; Italy; Turkmenistan; India; China; Croatia; Jordan; Spain; Bulgaria

Traditional Medicine System:

TCM; Homeopathy

Medicinal Functions:

Astringent; Bitter; Cholagogue; Diaphoretic; Diuretic; Emetic; Emmenagogue; Hepatic; Homeopathy; Stimulant; Stomachic; Tonic

Geographical Distribution:

Brazil; Afghanistan; Italy; Peru; Canada; Kuwait; France; Netherlands; Ireland; Argentina; Norway; Ecuador; Turkmenistan; Israel; Australia; Iran; Algeria; Turkey; Jordan; China; Chile; Belgium; Germany; Kazakhstan; Poland; Spain; Georgia; Libya; Denmark; Philippines; Indonesia; Saudi Arabia; United States; Morocco; Sweden; Belarus; Croatia; Thailand; Switzerland; New Zealand; Russia; Bulgaria; Pakistan; Portugal; Uruguay; Egypt; India; United Kingdom; Tunisia; Austria; Vietnam; Paraguay; Hungary; Taiwan; Cyprus

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; FFAR4; FFAR1; TAAR1;
Small molecule receptor (family C GPCR)	GRM1; GRM8;
Peptide receptor (family A GPCR)	NPSR1;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Protein Kinase	PRKCE; PRKCB; PRKCG; PRKCD; MET; AXL; KDR; FLT3; CDK1; PIM1; PRKCA; IGF1R; AURKB;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX12; HSD17B10; ALOX15; NOX4; POLB;
SLC superfamily of solute carriers	SLCO2B1; SLC1A1; SLCO1B1;
Unclassified	LMNA; FABP3; FABP5; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIA2	Glutamate receptor ionotropic, AMPA 2	P42262	CHEMBL4016
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	PRKCE	Protein kinase C epsilon	Q02156	CHEMBL3582
Protein Kinase	PRKCB	Protein kinase C beta	P05771	CHEMBL3045
Protein Kinase	PRKCG	Protein kinase C gamma	P05129	CHEMBL2938
Protein Kinase	PRKCD	Protein kinase C delta	Q05655	CHEMBL2996
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
SLC superfamily of solute carriers	SLCO2B1	Solute carrier organic anion transporter family member 2B1	O94956	CHEMBL1743124
SLC superfamily of solute carriers	SLC1A1	Excitatory amino acid transporter 3	P43005	CHEMBL2721
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	TAAR1	Trace amine-associated receptor 1	Q96RJ0	CHEMBL5857
Small molecule receptor (family C GPCR)	GRM1	Metabotropic glutamate receptor 1	Q13255	CHEMBL3772
Small molecule receptor (family C GPCR)	GRM8	Metabotropic glutamate receptor 8	O00222	CHEMBL3228
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	Unclassified;	GO:0004872; receptor activity	2.218E-10	4.025E-07	ADORA3, AXL, FFAR1, FFAR4, FLT3, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, GRM1, GRM8, IGF1R, KDR, MET, NPSR1, PPARA, TAAR1
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	2.928E-10	4.251E-07	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	1.640E-09	1.552E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0003824; catalytic activity	GO:0004698; calcium-dependent protein kinase C activity	3.040E-08	1.947E-05	PRKCA, PRKCB, PRKCG
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	3.570E-08	2.101E-05	AURKB, CDK1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	7.588E-08	3.516E-05	GRIK1, GRIK3, GRIK5
MF	GO:0005488; binding	GO:0005504; fatty acid binding	2.408E-07	8.456E-05	FABP3, FABP4, FABP5, FFAR4
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	2.630E-07	8.948E-05	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	6.339E-07	1.793E-04	GRIK3, GRM1, GRM8
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	1.755E-06	4.497E-04	ALOX12, FABP3, FABP4, FFAR1, GRIK5, GRM1, MET, NOX4, NPSR1, PRKCB, PRKCE
BP	GO:0009987; cellular process	GO:0007077; mitotic nuclear envelope disassembly	1.817E-06	4.601E-04	CDK1, LMNA, PRKCA, PRKCB
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.842E-06	4.611E-04	AXL, FLT3, IGF1R, KDR, MET, PRKCD
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	2.496E-06	5.788E-04	AURKB, FLT3, IGF1R, KDR, PIM1, PRKCG
MF	GO:0005488; binding	GO:0005524; ATP binding	3.571E-06	7.776E-04	AURKB, AXL, CDK1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG
BP	GO:0008152; metabolic process	GO:0035408; histone H3-T6 phosphorylation	3.972E-06	8.009E-04	PRKCA, PRKCB
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	3.972E-06	8.009E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	3.972E-06	8.009E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0035403; histone kinase activity (H3-T6 specific)	3.972E-06	8.009E-04	PRKCA, PRKCB
BP	GO:0008152; metabolic process	GO:0051054; positive regulation of DNA metabolic process	4.035E-06	8.061E-04	AURKB, CDK1, IGF1R, NOX4, PRKCD, PRKCG
BP	GO:0023052; signaling	GO:0051966; regulation of synaptic transmission, glutamatergic	5.961E-06	1.139E-03	GRIK1, GRIK3, GRM1, GRM8
BP	GO:0051179; localization	GO:0006811; ion transport	6.121E-06	1.149E-03	FABP3, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, PPARA, PRKCB, PRKCE, SLC1A1, SLCO1B1, SLCO2B1
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	6.815E-06	1.259E-03	AXL, CDK1, CYP1B1, PRKCD
BP	GO:0008152; metabolic process	GO:0050996; positive regulation of lipid catabolic process	1.141E-05	1.957E-03	PPARA, PRKCD, PRKCE
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.190E-05	1.994E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.190E-05	1.994E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004699; calcium-independent protein kinase C activity	1.190E-05	1.994E-03	PRKCD, PRKCE
BP	GO:0032502; developmental process	GO:0045766; positive regulation of angiogenesis	1.396E-05	2.252E-03	ALOX12, CYP1B1, KDR, PRKCA, PRKCB
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.697E-05	2.659E-03	FABP3, FABP4, FABP5
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	2.377E-05	3.581E-03	GRIA2, GRIA4
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	3.957E-05	5.129E-03	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	4.556E-05	5.604E-03	ALOX15, FFAR4, KDR, NOX4, PRKCA
BP	GO:0022610; biological adhesion	GO:0030155; regulation of cell adhesion	4.768E-05	5.800E-03	ALOX12, ALOX15, CYP1B1, KDR, PPARA, PRKCA, PRKCD, PRKCE
BP	GO:0065007; biological regulation	GO:0043405; regulation of MAP kinase activity	5.687E-05	6.767E-03	CDK1, FLT3, GRM1, IGF1R, NOX4, PRKCD
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	5.947E-05	7.000E-03	ADORA3, ALOX12, CDK1, CYP1B1, FABP3, FLT3, IGF1R, KDR, LMNA, NOX4, PIM1, PRKCA
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	6.312E-05	7.311E-03	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	8.289E-05	9.256E-03	FLT3, KDR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	1.846E-16	2.326E-14	PRKCG, GRIA2, PRKCB, GRIK5, SLC1A1, GRM8, GRIK3, PRKCA, GRIK1, GRM1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	1.704E-09	1.019E-07	PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.427E-09	1.019E-07	GRIA2, GRIK5, ADORA3, GRM8, GRIK3, GRIK1, TAAR1, GRM1, GRIA4
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3.394E-08	1.025E-06	PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, ALOX12
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	4.069E-08	1.025E-06	PRKCG, GRIA2, PRKCB, PRKCA, GRM1, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	1.911E-07	3.439E-06	PRKCG, GRIA2, PRKCB, PRKCA, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	1.771E-07	3.439E-06	PRKCG, GRIA2, PRKCB, PRKCA, GRM1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.493E-06	1.595E-05	PRKCB, PRKCE, PRKCD, PIM1, PRKCA
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	1.102E-06	1.388E-05	PRKCG, GRIA2, PRKCB, PRKCA, GRIA4
09150 Organismal Systems	09151 Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9.910E-07	1.387E-05	PRKCG, PRKCB, PRKCE, PRKCD, PRKCA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	7.523E-07	1.185E-05	PRKCG, PRKCB, CDK1, PRKCA, GRM1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.519E-06	1.595E-05	PRKCG, PRKCB, PRKCE, PIM1, CYP1B1, PRKCA, MET
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.506E-06	2.105E-05	PRKCG, PRKCB, KDR, PRKCA, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	2.436E-06	2.105E-05	PRKCG, PRKCB, KDR, PRKCA, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	3.134E-06	2.448E-05	PRKCG, PRKCB, KDR, PRKCA, MET, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.490E-06	2.105E-05	PRKCG, PRKCB, ALOX15, PRKCA, ALOX12
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	4.774E-06	3.142E-05	PRKCG, PRKCB, KDR, PRKCA, MET, IGF1R
09150 Organismal Systems	09153 Circulatory system	hsa04270	Vascular smooth muscle contraction	3.497E-06	2.448E-05	PRKCG, PRKCB, PRKCE, PRKCD, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	3.497E-06	2.448E-05	PRKCG, PRKCB, ADORA3, PRKCE, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	4.987E-06	3.142E-05	PRKCG, GRIA2, PRKCB, PRKCA, GRIA4
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	7.671E-06	4.203E-05	PRKCG, PRKCB, PRKCA, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	5.946E-06	3.568E-05	PRKCG, PRKCB, KDR, PRKCA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04530	Tight junction	7.182E-06	4.113E-05	PRKCG, PRKCB, PRKCE, PRKCD, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04925	Aldosterone synthesis and secretion	1.843E-05	9.291E-05	PRKCG, PRKCB, PRKCE, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04911	Insulin secretion	2.231E-05	1.081E-04	PRKCG, PRKCB, PRKCA, FFAR1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.104E-04	4.347E-04	PRKCG, PRKCB, FLT3, PRKCA, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	4.750E-05	2.138E-04	PRKCG, PRKCB, PRKCA, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	9.741E-06	5.114E-05	FABP3, FABP4, FABP5, PPARA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.927E-05	2.506E-04	PRKCB, PRKCE, PRKCD, PPARA
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	4.081E-04	1.390E-03	PRKCG, PRKCB, PRKCA, GRM1
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	4.038E-04	1.390E-03	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	1.769E-04	6.755E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	2.172E-04	8.050E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	6.488E-04	2.151E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	7.397E-04	2.219E-03	PRKCB, PRKCD, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	3.575E-04	1.287E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04727	GABAergic synapse	6.708E-04	2.167E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	6.933E-04	2.184E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09155 Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1.047E-04	4.258E-04	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	7.397E-04	2.219E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	1.315E-03	3.451E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04916	Melanogenesis	9.727E-04	2.664E-03	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04070	Phosphatidylinositol signaling system	9.173E-04	2.627E-03	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	1.001E-03	2.684E-03	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	9.727E-04	2.664E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	8.641E-04	2.532E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.567E-03	3.949E-03	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05143	African trypanosomiasis	4.297E-05	2.005E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09151 Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2.301E-03	5.686E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5.968E-05	2.506E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	2.656E-03	6.436E-03	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	2.873E-03	6.582E-03	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04072	Phospholipase D signaling pathway	2.763E-03	6.448E-03	GRM8, PRKCA, GRM1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	4.267E-03	9.137E-03	KDR, PRKCA, MET, IGF1R
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	1.567E-03	3.949E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04921	Oxytocin signaling pathway	3.589E-03	8.075E-03	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.278E-03	9.137E-03	CYP1B1, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	3.949E-03	8.730E-03	PRKCE, PRKCD
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	2.758E-03	6.448E-03	GRIA2, GRIA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	PRKCB;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3; ADORA3; PRKCB;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
NA: NA	Reperfusion injury and heart attacks	NA	PRKCD;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3; PRKCE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	GRM1;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GRM1;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	Acute myocardial infarction	I21-I22	PRKCD;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRM1; GRIK1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	GRM1;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Renal transplantation	D89.8	PRKCB;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRM1; CDK1; IGF1R; GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	GRIA2; GRIA4;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Central nervous system tumors	NA	PRKCB;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
NA: NA	GIST	NA	FLT3;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRM1; NPSR1; GRIK1;
I00-I99: Diseases of the circulatory system	Ischemic reperfusion injury	I00-I99	PRKCE;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
C00-D49: Neoplasms	Lymphoma	C81-C86	PRKCB;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	PRKCB;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Brain cancer	C71, D33	PRKCB;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases