Plant Name: Garcinia livingstonei
Taxonomic Information:
Plant ID: NPO5638
Plant Latin Name: Garcinia livingstonei
Taxonomy Genus: Garcinia
Taxonomy Family: Clusiaceae
Plant External Links:
NCBI TaxonomyDB:
469932
Plant-of-the-World-Online:
428049-1
Used in Medicines:
Country/Region:
Madagascar; Angola; South Africa; Tanzania; Zimbabwe; Rwanda; Swaziland; KenyaTraditional Medicine System:
Geographical Distribution:
Madagascar; Guinea; Malawi; Ethiopia; Rwanda; Somalia; Swaziland; Nigeria; Cameroon; Cote d'Ivoire; Ghana; Australia; Zambia; Burkina Faso; Togo; Zimbabwe; Germany; Tanzania; Namibia; Guinea-Bissau; Mali; Angola; South Africa; Comoros; Senegal; Mozambique; Uganda; Kenya; Botswana
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CTSB | Cathepsin B | P07858 | CHEMBL4072 |
| Serine protease | CTSG | Cathepsin G | P08311 | CHEMBL4071 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004252; serine-type endopeptidase activity | 1.642E-04 | 9.316E-01 | CTSB, CTSG |
| BP | GO:0002376; immune system process | GO:0043312; neutrophil degranulation | 6.214E-04 | 9.391E-01 | CTSB, CTSG |
| CC | GO:0044464; cell part | GO:0036021; endolysosome lumen | 5.177E-04 | 9.391E-01 | CTSB |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 2.817E-02 | 1.000E+00 | CTSB |
| CC | GO:0044464; cell part | GO:0034774; secretory granule lumen | 3.296E-02 | 1.000E+00 | CTSG |
| MF | GO:0003824; catalytic activity | GO:0008234; cysteine-type peptidase activity | 2.040E-02 | 1.000E+00 | CTSB |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 3.752E-05 | 3.001E-04 | CTSG, CTSB |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04614 | Renin-angiotensin system | 2.299E-03 | 9.195E-03 | CTSG |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04924 | Renin secretion | 6.390E-03 | 1.537E-02 | CTSB |
| 09150 Organismal Systems | 09151 Immune system | hsa04612 | Antigen processing and presentation | 7.685E-03 | 1.537E-02 | CTSB |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 9.975E-03 | 1.594E-02 | CTSG |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.395E-02 | 1.594E-02 | CTSB |
| 09160 Human Diseases | 09162 Immune diseases | hsa05322 | Systemic lupus erythematosus | 1.345E-02 | 1.594E-02 | CTSG |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 2.751E-02 | 2.751E-02 | CTSG |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
