CMAUP Plant Collective Molecular Activities

Plant Name: Harpagophytum procumbens

Taxonomic Information:

Plant ID: NPO5565
Plant Latin Name: Harpagophytum procumbens
Taxonomy Genus: Harpagophytum
Taxonomy Family: Pedaliaceae

Plant External Links:

NCBI TaxonomyDB: 222879
Plant-of-the-World-Online: 675824-1

Used in Medicines:

Country/Region:

Madagascar; Angola; South Africa; Zimbabwe; China; Swaziland

Traditional Medicine System:

TCM

Geographical Distribution:

Madagascar; Angola; South Africa; Lesotho; Zimbabwe; Namibia; Swaziland; China; Botswana

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	HCAR2;
Protein Kinase	PRKCA;
Enzyme_unclassified	HSD17B10;
Metallo protease	MMP12; MMP2;
Transcription Factor	HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0032963; collagen metabolic process	2.457E-06	2.759E-02	HIF1A, MMP12, MMP2
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	2.944E-06	2.759E-02	HIF1A, MMP12, MMP2
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	5.533E-06	2.759E-02	HIF1A, MMP12, MMP2
BP	GO:0002376; immune system process	GO:0002684; positive regulation of immune system process	7.478E-06	2.759E-02	HCAR2, HIF1A, MMP12, MMP2, PRKCA
BP	GO:0009987; cellular process	GO:0050708; regulation of protein secretion	7.603E-06	2.759E-02	HCAR2, HIF1A, MMP12, PRKCA
BP	GO:0008283; cell proliferation	GO:0050679; positive regulation of epithelial cell proliferation	2.491E-05	6.780E-02	HIF1A, MMP12, PRKCA
BP	GO:0023052; signaling	GO:0046883; regulation of hormone secretion	8.388E-05	9.304E-02	HCAR2, HIF1A, PRKCA
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	7.237E-04	2.466E-01	MMP12, MMP2
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	7.247E-04	2.466E-01	TSHR
MF	GO:0003824; catalytic activity	GO:0035403; histone kinase activity (H3-T6 specific)	7.247E-04	2.466E-01	PRKCA
MF	GO:0003824; catalytic activity	GO:0004698; calcium-dependent protein kinase C activity	1.449E-03	3.187E-01	PRKCA
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.289E-03	3.925E-01	MMP12, MMP2, PRKCA
CC	GO:0044421; extracellular region part	GO:0005578; proteinaceous extracellular matrix	4.191E-03	5.155E-01	MMP12, MMP2
CC	GO:0016020; membrane	GO:0005886; plasma membrane	8.473E-03	7.624E-01	HCAR2, HSD17B10, MMP2, PRKCA, TSHR
CC	GO:0044464; cell part	GO:0005739; mitochondrion	8.520E-03	7.635E-01	HSD17B10, MMP2, PRKCA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	3.500E-05	2.450E-03	MMP2, PRKCA, HIF1A
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.560E-04	4.514E-03	MMP2, PRKCA, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	1.841E-04	4.514E-03	PRKCA, HIF1A
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	2.580E-04	4.514E-03	PRKCA, TSHR
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5.216E-04	4.746E-03	MMP2, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	4.237E-04	4.746E-03	MMP2, PRKCA
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	5.216E-04	4.746E-03	PRKCA, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	5.424E-04	4.746E-03	PRKCA, HIF1A
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	7.110E-04	4.977E-03	PRKCA, HIF1A
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	7.110E-04	4.977E-03	MMP2, PRKCA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases