Plant Name: Hypericum prolificum
Taxonomic Information:
Plant ID: NPO5547
Plant Latin Name: Hypericum prolificum
Taxonomy Genus: Hypericum
Taxonomy Family: Hypericaceae
Plant External Links:
NCBI TaxonomyDB:
269015
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| GPBAR1; | |
| BLM; ALOX15; HSD17B10; AKR1B10; | |
| PIM1; CSNK2A1; | |
| NR1H4; | |
| ESR1; ESR2; | |
| HIF1A; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0046914; transition metal ion binding | 3.949E-07 | 4.085E-03 | ALOX15, BLM, CYP2C9, CYP3A4, ESR1, ESR2, NR1H4, PIM1 |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 4.815E-07 | 4.085E-03 | CYP3A4, ESR1, ESR2, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 5.629E-07 | 4.085E-03 | ESR1, ESR2 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 8.881E-07 | 4.369E-03 | AKR1B10, CYP2C9, CYP3A4, ESR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.688E-06 | 5.250E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 1.688E-06 | 5.250E-03 | GPBAR1, NR1H4 |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 3.374E-06 | 7.347E-03 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 3.374E-06 | 7.347E-03 | CYP2C9, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0009755; hormone-mediated signaling pathway | 6.830E-06 | 1.063E-02 | ESR1, ESR2, NR1H4, TSHR |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 8.219E-06 | 1.147E-02 | ESR1, ESR2, NR1H4, PIM1 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 8.428E-06 | 1.147E-02 | CYP2C9, CYP3A4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.233E-06 | 6.286E-05 | CYP2C9, ALOX15, CYP3A4 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 9.673E-04 | 9.544E-03 | CYP2C9, ALOX15 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.063E-03 | 9.544E-03 | CYP2C9, CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.302E-03 | 9.544E-03 | ESR1, ESR2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.196E-03 | 9.544E-03 | CYP2C9, CYP3A4 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.610E-03 | 9.544E-03 | CYP2C9, AKR1B10, ALOX15, CYP3A4, HSD17B10 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.266E-03 | 9.544E-03 | NR1H4, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.338E-03 | 9.544E-03 | CYP2C9, CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 2.442E-03 | 1.245E-02 | ESR1, ESR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.684E-03 | 9.544E-03 | CYP2C9, CYP3A4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
