Plant Name: Hortia arborea
Taxonomic Information:
Plant ID: NPO5476
Plant Latin Name: Hortia arborea
Taxonomy Genus: Hortia
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CTSV | Cathepsin L2 | O60911 | CHEMBL3272 |
| Phosphodiesterase 4 | PDE4D | Phosphodiesterase 4D | Q08499 | CHEMBL288 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032502; developmental process | GO:0007568; aging | 1.424E-04 | 9.018E-01 | CTSV, PDE4D |
| BP | GO:0032501; multicellular organismal process | GO:1901898; negative regulation of relaxation of cardiac muscle | 2.071E-04 | 9.018E-01 | PDE4D |
| BP | GO:0051179; localization | GO:0032412; regulation of ion transmembrane transporter activity | 2.285E-02 | 1.000E+00 | PDE4D |
| BP | GO:0051179; localization | GO:0051924; regulation of calcium ion transport | 2.326E-02 | 1.000E+00 | PDE4D |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 1.187E-02 | 1.000E+00 | CTSV |
| MF | GO:0003824; catalytic activity | GO:0016787; hydrolase activity | 1.835E-02 | 1.000E+00 | CTSV, PDE4D |
| MF | GO:0003824; catalytic activity | GO:0004252; serine-type endopeptidase activity | 2.551E-02 | 1.000E+00 | CTSV |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09164 Substance dependence | hsa05032 | Morphine addiction | 9.080E-03 | 1.980E-02 | PDE4D |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.395E-02 | 1.980E-02 | CTSV |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.226E-02 | 1.980E-02 | CTSV |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 1.980E-02 | 1.980E-02 | PDE4D |
| 09100 Metabolism | 09104 Nucleotide metabolism | hsa00230 | Purine metabolism | 1.752E-02 | 1.980E-02 | PDE4D |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
