CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; GPR35;
Enzyme_unclassified	RECQL; TDP1; ADK; HPGD; AKR1B1; APEX1; POLB;
Hydrolase	ACHE;
Protein Kinase	TEK; MET; INSR; NUAK1; EGFR; KDR; SRC; IGF1R; CSNK2A1;
Lyase	CA2; CA1; CA12; CA9; CA7; CA14;
Lysine demethylase	KDM4E;
Oxidoreductase	PTGS2;
Transcription Factor	STAT1;
Transferase	FUT7;
Plant homeodomain	KMT2A;
SLC superfamily of solute carriers	SLC22A6;
Unclassified	SMAD3; RAB9A; LMNA; NPC1; THPO; HSPA1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392

Showing 1 to 10 of 42 entries

Previous1 2 3 4 5Next

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.834E-10	6.192E-07	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.363E-08	7.809E-06	CA1, CA12, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	5.448E-08	2.524E-05	EGFR, IGF1R, INSR, KDR, SRC
BP	GO:0008283; cell proliferation	GO:0048661; positive regulation of smooth muscle cell proliferation	6.265E-07	1.819E-04	AKR1B1, EGFR, HPGD, PTGS2, STAT1
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	7.957E-07	2.113E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	8.930E-07	2.288E-04	EGFR, INSR, MET, SRC, TEK, THPO
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.135E-06	2.746E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	1.299E-06	3.041E-04	ADORA1, CYP1A1, LMNA, PTGS2, SMAD3, SRC, TEK
BP	GO:0008152; metabolic process	GO:0045429; positive regulation of nitric oxide biosynthetic process	1.844E-06	4.016E-04	EGFR, INSR, PTGS2, SMAD3
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	1.984E-06	4.235E-04	ADORA1, ADORA2A, ADORA3, CYP1B1, HSPA1A, KMT2A, LMNA, PTGS2, SMAD3, STAT1

Showing 1 to 10 of 50 entries

Previous1 2 3 4 5Next

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.953E-25	3.515E-23	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14, CA13
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.351E-04	5.845E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.752E-04	6.857E-04	ALOX15, CYP2C19, PTGS2, PTGS1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.105E-04	7.578E-04	CYP1A2, ALDH1A1, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.293E-04	1.078E-03	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.355E-06	5.186E-05	CYP1A2, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.726E-03	7.890E-03	CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	7.718E-04	2.205E-03	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.114E-11	6.684E-10	PDGFRB, SRC, INSR, FLT4, BRAF, EGFR, IGF1R, ADORA2A, KDR, AKT1, MAPK1, TEK, MET
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	4.135E-09	6.203E-08	PDGFRB, GSK3B, INSR, FLT4, PTK2, EGFR, IGF1R, KDR, AKT1, MAPK1, TEK, TP53, MET

Showing 1 to 10 of 91 entries

Previous1 2 3 4 5…10Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; SRC;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	INSR; EGFR; CA9;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;

Showing 1 to 10 of 160 entries

Previous1 2 3 4 5…16Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cynoglossum amabile

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities