CMAUP Plant Collective Molecular Activities

Plant Name: Vachellia pennatula

Taxonomic Information:

Plant ID: NPO5429
Plant Latin Name: Vachellia pennatula
Taxonomy Genus: Vachellia
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 138038
Plant-of-the-World-Online: 60441228-2

Used in Medicines:

Country/Region:

Mexico

Traditional Medicine System:

Geographical Distribution:

Honduras; Peru; Mexico; El Salvador; Venezuela; Guatemala; Colombia; Nicaragua; Ecuador

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Protein Kinase	FLT3;
Lyase	CA7; CA4; CA12;
Enzyme_unclassified	NOX4; AKR1B10; AKR1B1;
Metallo protease	MMP1; MMP9; MMP12; MMP2;
Transcription Factor	NFKB1; HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.998E-12	6.527E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.398E-10	1.015E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0020037; heme binding	1.902E-09	8.239E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.959E-09	1.077E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.850E-09	1.415E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	1.722E-08	2.884E-05	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	4.950E-08	7.062E-05	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.644E-07	3.174E-04	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.878E-07	3.248E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	4.357E-07	3.388E-04	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	9.586E-07	6.325E-04	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.411E-06	8.780E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	3.358E-06	1.700E-03	AKR1B1, CYP19A1, CYP1A2, NOX4
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	4.313E-06	1.998E-03	MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	4.736E-06	2.148E-03	CYP19A1, CYP1A1, CYP2C19
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	5.494E-06	2.392E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.644E-06	2.410E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.370E-06	3.028E-03	CA12, CA4, CA7, MMP1, MMP12, MMP2, MMP9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.042E-05	3.911E-03	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.372E-05	5.063E-03	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	1.675E-05	5.883E-03	AKR1B1, CYP19A1, CYP1A2, NOX4
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	1.816E-05	6.082E-03	CYP1A1, CYP1B1, FLT3, NFKB1, NOX4
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	2.558E-05	7.956E-03	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0044598; doxorubicin metabolic process	2.558E-05	7.956E-03	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.558E-05	7.956E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.284E-06	2.761E-05	FLT3, MMP1, MMP2, HIF1A, MMP9, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.389E-07	2.054E-05	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	9.706E-07	2.761E-05	CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	7.024E-06	1.086E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.901E-07	2.108E-05	CA12, CA4, CA7
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.385E-05	1.702E-04	CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	7.574E-06	1.086E-04	MMP1, MMP2, MMP9
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.335E-05	4.660E-04	CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	7.523E-04	4.621E-03	AKR1B10, CYP1A2, CYP1A1, AKR1B1, CYP2C19, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	8.855E-04	5.077E-03	MMP2, HIF1A, MMP9
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.247E-04	4.133E-03	FLT3, MMP9, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.419E-04	3.148E-03	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.323E-03	7.110E-03	FLT3, NFKB1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5.284E-04	3.787E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	3.661E-04	3.148E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.417E-03	7.166E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4.170E-04	3.260E-03	AKR1B10, AKR1B1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.822E-03	8.248E-03	FLT3, HIF1A
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.716E-03	8.199E-03	CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.931E-03	8.304E-03	CYP1A2, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; FLT3; ACHE; HIF1A; MMP9; MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; MMP1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
C00-D49: Neoplasms	Breast cancer	C50	FLT3; CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Solid tumours	C00-D48	FLT3; HIF1A; MMP9; MMP2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
NA: NA	Upper abdominal bloating	NA	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	AML	NA	FLT3;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	FLT3; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	FLT3; MMP9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases