Plant ID: NPO5406
Plant Latin Name: Veronica chamaedrys
Taxonomy Genus: Veronica
Taxonomy Family: Plantaginaceae
NCBI TaxonomyDB:
165330
Plant-of-the-World-Online:
811804-1
Blood purifier; Skin; Vulnerary
Turkey; Italy; France; Ireland; Norway; Belarus; Iceland; Germany; Belgium; Kazakhstan; Spain; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Sweden; Switzerland; Russia; Bulgaria; Romania; Albania; Portugal; South Africa; United Kingdom; Austria; Greece; Hungary
ACHE; | |
CSNK2A1; | |
CA7; CA4; CA12; | |
ESR2; | |
NR1H4; | |
HSD17B1; | |
THPO; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.084E-09 | 1.991E-05 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.809E-08 | 7.880E-05 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 2.850E-08 | 1.034E-04 | CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.078E-07 | 2.936E-04 | CA12, CA4, CA7 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 3.145E-07 | 6.849E-04 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 4.185E-07 | 6.940E-04 | CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0005488; binding | GO:0020037; heme binding | 1.256E-06 | 1.609E-03 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.679E-06 | 1.944E-03 | CA12, CA4, CA7 |
BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 2.507E-06 | 2.729E-03 | CYP1A1, CYP1A2 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.104E-06 | 2.939E-03 | CA12, CA4, CA7 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 3.059E-06 | 2.939E-03 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0050665; hydrogen peroxide biosynthetic process | 1.168E-05 | 8.478E-03 | CYP1A1, CYP1A2 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 3.402E-09 | 4.559E-07 | HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 9.010E-08 | 3.018E-06 | HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 2.827E-08 | 1.894E-06 | CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19, PTGS2 |
Unclassified | Unclassified | hsa01100 | Metabolic pathways | 3.096E-07 | 8.298E-06 | MAOA, GAA, ALOX15, AKR1B1, PTGS2, CYP2C19, CYP3A4, CYP19A1, PKM, HSD17B1, CYP1A2, CYP1A1, ALPI, XDH |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 5.346E-07 | 1.023E-05 | CA2, NR1H4, CYP3A4, CFTR, ABCG2 |
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 5.208E-08 | 2.326E-06 | CA12, CA2, CA4, CA7 |
09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 1.926E-06 | 3.226E-05 | MAOA, CYP1A2, CYP1A1, CYP1B1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.096E-07 | 1.023E-05 | CYP1A2, ALOX15, CYP3A4, CYP2C19 |
09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 2.727E-05 | 3.045E-04 | AR, GSK3B, CDK6, FLT3, PTGS2, HIF1A, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.545E-05 | 2.301E-04 | PKM, FLT3, TP53, HIF1A |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.737E-05 | 2.328E-04 | MAOA, CYP1A2, CYP3A4, CYP2C19 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.173E-05 | 2.647E-04 | CYP1A2, CYP1A1, CYP1B1, CYP3A4 |
09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 9.433E-05 | 9.029E-04 | POLB, CDK6, PKM, SYK, TP53 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.163E-04 | 1.039E-03 | MAOA, ALOX15, CYP2C19, PTGS2 |
09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.423E-04 | 1.122E-03 | GSK3B, TP53, ESR1, HIF1A |
09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 2.455E-04 | 1.828E-03 | GSK3B, CDK6, CSNK2A1, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 5.245E-04 | 3.347E-03 | ABCC1, CDK6, CYP1B1, PTGS2, TP53 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 3.669E-04 | 2.587E-03 | ALOX15, CYP2C19, PTGS2 |
09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 5.695E-04 | 3.469E-03 | GSK3B, ESR1, ESR2 |
09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 1.089E-03 | 5.835E-03 | GSK3B, SYK, CSNK2A1, TP53 |
09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 1.322E-04 | 1.107E-03 | ABCC1, CFTR, ABCG2 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 4.217E-04 | 2.826E-03 | CYP1A2, CYP1A1, CYP3A4 |
09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.056E-03 | 5.835E-03 | GSK3B, AR, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 9.561E-04 | 5.570E-03 | CDK6, PTGS2, TP53 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 1.199E-03 | 6.031E-03 | SYK, CSNK2A1, PTGS2 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 2.069E-03 | 9.900E-03 | GAA, AKR1B1 |
09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 1.215E-03 | 6.031E-03 | CA2, CA4 |
09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 4.929E-05 | 5.081E-04 | CYP1A2, XDH |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Cancer | C00-C96 | CSNK2A1; ACHE; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; |
C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1; |
N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1; |
C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; |
A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; |
C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1; |
A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4; ACHE; |
H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE; |
NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE; |
N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE; |
NA: NA | Upper abdominal bloating | NA | ACHE; |
N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1; |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE; |
K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE; |
H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; |
C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1; |