CMAUP Plant Collective Molecular Activities

Plant Name: Citrus x paradisi

Taxonomic Information:

Plant ID: NPO5386
Plant Latin Name: Citrus x paradisi
Taxonomy Genus: Citrus
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 37656
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk

Geographical Distribution:

India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA;
Enzyme_unclassified	ALOX15;
Toll-like and Il-1 receptors	TLR2;
Unclassified	MAPT; FABP3; FABP2; FABP4; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	7.155E-10	3.895E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	6.452E-06	7.805E-03	FABP3, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	9.679E-06	1.018E-02	LMNA, PPARA, PPARD, TLR2
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	9.821E-06	1.018E-02	ALOX15, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	1.638E-05	1.321E-02	ALOX15, FABP3, PPARA, PPARD
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	1.617E-05	1.321E-02	FABP3, PPARD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.152E-13	2.522E-11	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4.167E-04	8.543E-03	FABP4, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	5.107E-03	6.980E-02	PPARA, TSHR
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	4.841E-02	1.024E-01	LMNA
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	5.366E-02	1.024E-01	TLR2
09160 Human Diseases	09162 Immune diseases	hsa05323	Rheumatoid arthritis	4.841E-02	1.024E-01	TLR2
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	5.679E-02	1.024E-01	TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	5.575E-02	1.024E-01	TLR2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.836E-02	1.024E-01	PPARA
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.992E-02	1.024E-01	ALOX15

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases