CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	HTR6;
Enzyme_unclassified	TDP1; RECQL; MTOR;
Lyase	ODC1;
Oxidoreductase	MT-ND4;
Transcription Factor	TP53;
Unclassified	MAPT; PMP22; GMNN; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Lyase	ODC1	Ornithine decarboxylase	P11926	CHEMBL1869
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Oxidoreductase	MT-ND4	NADH-ubiquinone oxidoreductase chain 4	P03905	CHEMBL4499
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371

Showing 1 to 10 of 15 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.428E-06	1.835E-01	CYP2C19, CYP2D6
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	2.020E-05	1.861E-01	RECQL, TP53
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	2.677E-05	1.861E-01	MAPT, MTOR, TP53
BP	GO:0008152; metabolic process	GO:2000379; positive regulation of reactive oxygen species metabolic process	4.274E-05	1.861E-01	MAPT, MTOR, TP53
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	6.582E-05	2.389E-01	LMNA, MTOR, TP53
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	2.103E-04	3.570E-01	MAPT, TP53
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.113E-04	3.570E-01	CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.466E-04	3.570E-01	CYP2C19, CYP2D6
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	1.553E-03	5.046E-01	TSHR

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.364E-03	2.354E-02	CYP2D6, CYP2C19
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	8.152E-03	6.250E-02	SMN2, SMN1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.078E-02	7.027E-02	HTR6, TSHR
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	5.475E-03	4.722E-02	LMNA, TP53
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.078E-05	6.264E-03	HTR6, CYP2D6, CYP2C19
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	2.513E-03	2.889E-02	TP53, MTOR
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.924E-03	3.868E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.212E-03	2.354E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.287E-03	2.354E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	2.256E-03	2.889E-02	TP53, MTOR

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR;
C00-D49: Neoplasms	Sarcoma	C81-C86	MTOR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR;
C00-D49: Neoplasms	Cancer	C00-C96	MTOR;
C00-D49: Neoplasms	Renal cancer	C64	MTOR;
C00-D49: Neoplasms	Solid tumors	NA	MTOR;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR;
C00-D49: Neoplasms	Advanced kidney cancer	C64	MTOR;
C00-D49: Neoplasms	Bladder cancer	C67	MTOR;

Showing 1 to 10 of 33 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Achillea cretica

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities