CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	TDP1; BLM; PIK3CA; PIK3CB; HSD11B1; AKR1B10; ALOX12; HSD17B2; HSD17B10; ALOX15; NOX4; NQO2; POLB;
Protein Phosphatase	CDC25B;
Protein Kinase	AURKB; MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R;
Lyase	CA12; CA9; CA14; CA7;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR; PTGS2;
Transcription Factor	AHR;
Unclassified	LMNA; FABP3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A1; CYP3A4; CYP1A2; CYP1B1;

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903

Showing 1 to 10 of 40 entries

Previous1 2 3 4Next

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	9.544E-08	6.298E-05	ALOX12, AURKB, AXL, CDK1, FFAR4, IGF1R, KDR, LMNA, NR1H4, PIK3CA, PIM1, PTGS2
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	9.773E-07	3.547E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.016E-06	6.361E-04	CA12, CA14, CA7, CA9
BP	GO:0050896; response to stimulus	GO:0010243; response to organonitrogen compound	2.489E-06	7.324E-04	BLM, CDK1, FABP3, FFAR4, FLT3, IGF1R, NOX4, NR1H4, PTGS2, TYR
BP	GO:0050896; response to stimulus	GO:0006954; inflammatory response	2.535E-06	7.361E-04	ALOX15, AXL, NOX4, NR1H4, PIK3CA, PIK3CB, POLB, PTGS2
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	4.181E-06	1.047E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	4.522E-06	1.106E-03	ALOX12, ALOX15, PTGS2
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	6.858E-06	1.493E-03	BLM, CYP1A1, CYP1B1, ESR1, FLT3, NOX4, PTGS2
BP	GO:0032502; developmental process	GO:0007568; aging	7.489E-06	1.583E-03	AURKB, CDK1, CYP1A1, NOX4, POLB, PTGS2
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.066E-05	2.211E-03	CYP1A1, CYP1A2, CYP1B1

Showing 1 to 10 of 37 entries

Previous1 2 3 4Next

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.621E-09	2.059E-07	HSD11B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.358E-07	8.529E-06	HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.203E-08	1.356E-06	CA12, CA7, CA9, CA14
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.956E-05	5.196E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.583E-04	1.562E-03	ALOX15, ALOX12, PTGS2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.612E-05	2.370E-04	CYP1A2, ALOX15, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.971E-04	1.572E-03	CYP1A2, CYP1A1, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	6.592E-06	9.302E-05	PIK3CA, KDR, PIK3CB, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	6.073E-05	4.820E-04	PIK3CA, KDR, PIK3CB, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	8.579E-05	6.053E-04	PIK3CA, KDR, PIK3CB, MET, IGF1R

Showing 1 to 10 of 44 entries

Previous1 2 3 4 5Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	PIK3CA;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1; FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;

Showing 1 to 10 of 139 entries

Previous1 2 3 4 5…14Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Dryopteris crassirhizoma

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities