CMAUP Plant Collective Molecular Activities

Plant Name: Zanthoxylum bungeanum

Taxonomic Information:

Plant ID: NPO5315
Plant Latin Name: Zanthoxylum bungeanum
Taxonomy Genus: Zanthoxylum
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 328401
Plant-of-the-World-Online: 775625-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Anaesthetic; Anthelmintic; Aromatic; Astringent; Carminative; Diaphoretic; Diuretic; Emmenagogue; Stimulant; Vasodilator; Vermifuge

Geographical Distribution:

Nepal; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	ALPL; ALOX12; HSD17B10; NOX4; ALDH1A1; POLB;
Hydrolase	ACHE;
Protein Kinase	MET; AXL; FLT3; CDK1; MAPK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA7;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Transcription Factor	TP53; NFKB1;
Unclassified	LMNA; FABP5; FABP4; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	7.427E-07	5.054E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, NFKB1, PIM1, TP53
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	5.457E-06	2.242E-03	ALPL, AXL, CNR1, CNR2, CYP1A2, NFKB1
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	6.426E-06	2.527E-03	ALOX12, IGF1R, KDR, MAPK1, MET, NOX4, TP53
MF	GO:0005488; binding	GO:0019902; phosphatase binding	6.943E-06	2.652E-03	MAPK1, MAPT, MET, PPARA, TP53
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	7.968E-06	2.894E-03	CNR1, CNR2
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.279E-05	3.816E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	1.591E-05	4.531E-03	ALOX12, CA7, CNR1, FABP4, MAPK1, MET, NOX4, NPSR1, TP53
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	1.592E-05	4.531E-03	CNR1, CNR2
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.647E-05	4.541E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0044255; cellular lipid metabolic process	1.880E-05	4.991E-03	ACHE, ALDH1A1, ALOX12, CYP1A2, CYP1B1, FABP4, FABP5, MET, PPARA
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	1.983E-05	5.201E-03	CA7, CNR1, CNR2
BP	GO:0009987; cellular process	GO:1902533; positive regulation of intracellular signal transduction	2.073E-05	5.310E-03	AXL, CDK1, CYP1B1, FLT3, KDR, MAPK1, MET, NOX4, TP53
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	2.097E-05	5.310E-03	ALPL, CYP1B1, FLT3, MAPK1, NFKB1, NOX4
MF	GO:0005488; binding	GO:0042802; identical protein binding	3.640E-05	8.342E-03	ACHE, FLT3, IGF1R, KDR, MAPK1, MAPT, MET, NFKB1, SMN1, SMN2, TP53
CC	GO:0044464; cell part	GO:0043204; perikaryon	3.769E-05	8.461E-03	CNR2, MAPK1, SMN1, SMN2
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	3.899E-05	8.664E-03	CDK1, CNR1, POLB, TP53
BP	GO:0050896; response to stimulus	GO:0035094; response to nicotine	4.218E-05	9.050E-03	CNR1, MAPK1, NFKB1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.008E-06	2.351E-04	FLT3, PIM1, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.854E-06	2.351E-04	FLT3, MAPK1, TP53, MET
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	4.863E-06	2.351E-04	MAPK1, TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	6.675E-06	2.420E-04	PIM1, CYP1B1, MAPK1, TP53, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.465E-05	2.791E-04	KDR, MAPK1, TP53, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.198E-05	2.791E-04	MAPK1, TP53, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.652E-05	2.791E-04	KDR, MAPK1, TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.732E-05	2.791E-04	POLB, CDK1, MAPK1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	9.235E-06	2.678E-04	FLT3, TP53, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.990E-05	2.886E-04	CNR1, KDR, MAPK1, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.448E-05	4.166E-04	FLT3, MAPK1, MET, TP53, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.827E-05	3.726E-04	KDR, MAPK1, MET, NFKB1, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.102E-05	7.356E-04	LMNA, MAPK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	5.817E-05	6.488E-04	MAPK1, PPARA, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.519E-04	1.441E-03	MAPK1, TP53, IGF1R
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.590E-04	1.441E-03	MAPK1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.749E-04	1.993E-03	MAPK1, PPARA, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.144E-04	1.704E-03	MAPK1, TP53, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	2.910E-04	2.009E-03	KDR, MAPK1, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.233E-04	1.704E-03	MAPK1, MET, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5.574E-04	3.368E-03	PIM1, MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.814E-04	1.548E-03	FABP4, FABP5, PPARA
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	4.518E-04	2.978E-03	TP53, NFKB1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5.104E-04	3.218E-03	CDK1, MAPK1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	7.009E-04	3.909E-03	MAPK1, MAPT, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	5.902E-04	3.423E-03	MAPK1, NFKB1, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	9.202E-04	4.765E-03	MAPK1, TP53, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	9.883E-04	4.777E-03	CDK1, MAPK1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	9.202E-04	4.765E-03	MAPK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.619E-03	7.570E-03	MAPK1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.956E-03	8.595E-03	MAPK1, TP53
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.862E-03	8.439E-03	CYP1A2, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	9.801E-04	4.777E-03	MAPK1, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	CNR1; MAPT;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CNR1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	CNR1;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR2; CDK1; IGF1R; ACHE; CNR1;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; MAPT;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
NA: NA	Upper abdominal bloating	NA	ACHE;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	CNR1;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	CNR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	CNR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR2; CNR1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	CNR1;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CNR1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CNR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CNR2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chemotherapy-induced nausea	R11	CNR1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; TP53;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Melanoma	C43	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; MAPT;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	CNR1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; CNR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anorexia	F50.0-F50.1	CNR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; CNR1;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Glioma	C71	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	CNR1;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; MAPK1; TP53;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	CNR1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; MAPK1; TP53;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CNR1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases