CMAUP Plant Collective Molecular Activities

Plant Name: Nephelium mutabile

Taxonomic Information:

Plant ID: NPO53
Plant Latin Name: Nephelium mutabile
Taxonomy Genus: Nephelium
Taxonomy Family: Sapindaceae

Plant External Links:

NCBI TaxonomyDB: 290979
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Malaysia

Traditional Medicine System:

Geographical Distribution:

Malaysia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 1 group H	NR1H4;
ATP-binding cassette	ABCG2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.106E-04	2.818E-01	NR1H4
MF	GO:0060089; molecular transducer activity	GO:0004887; thyroid hormone receptor activity	7.247E-04	4.641E-01	NR1H4
MF	GO:0005215; transporter activity	GO:0008559; xenobiotic transmembrane transporting ATPase activity	7.247E-04	4.641E-01	ABCG2
MF	GO:0005488; binding	GO:0046965; retinoid X receptor binding	1.553E-03	5.931E-01	NR1H4
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	3.306E-02	1.000E+00	ABCG2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.243E-05	2.485E-05	NR1H4, ABCG2
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	4.395E-03	4.395E-03	ABCG2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases