Plant ID: NPO5287
Plant Latin Name: Strychnos cathayensis
Taxonomy Genus: Strychnos
Taxonomy Family: Loganiaceae
NCBI TaxonomyDB:
1603838
Plant-of-the-World-Online:
n.a.
ALPL; HSD17B10; | |
GAA; | |
NFKB1; |
Cytochrome P450 Enzymes: |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0000023; maltose metabolic process | 6.212E-04 | 7.512E-01 | GAA |
BP | GO:0050896; response to stimulus | GO:0032496; response to lipopolysaccharide | 1.206E-03 | 7.512E-01 | ALPL, NFKB1 |
CC | GO:0032991; macromolecular complex | GO:0033256; I-kappaB/NF-kappaB complex | 1.449E-03 | 7.512E-01 | NFKB1 |
MF | GO:0003824; catalytic activity | GO:0004574; oligo-1,6-glucosidase activity | 4.141E-04 | 7.512E-01 | GAA |
MF | GO:0003824; catalytic activity | GO:0032450; maltose alpha-glucosidase activity | 6.212E-04 | 7.512E-01 | GAA |
MF | GO:0003824; catalytic activity | GO:0004558; alpha-1,4-glucosidase activity | 8.281E-04 | 7.512E-01 | GAA |
MF | GO:0003824; catalytic activity | GO:0004035; alkaline phosphatase activity | 1.242E-03 | 7.512E-01 | ALPL |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.096E-02 | 3.785E-02 | NFKB1 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00790 | Folate biosynthesis | 2.797E-03 | 3.785E-02 | ALPL |
09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 1.294E-02 | 3.785E-02 | NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.314E-02 | 3.785E-02 | NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.135E-02 | 3.785E-02 | NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.353E-02 | 3.785E-02 | NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 1.274E-02 | 3.785E-02 | NFKB1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.432E-02 | 3.785E-02 | NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 1.452E-02 | 3.785E-02 | NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 1.294E-02 | 3.785E-02 | NFKB1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |