Plant Name: Dorycnium hirsutum
Taxonomic Information:
Plant ID: NPO528
Plant Latin Name: Dorycnium hirsutum
Taxonomy Genus: Dorycnium
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
118898
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| P4HB; AKR1B1; | |
| PPARD; PPARA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | P4HB | Protein disulfide-isomerase | P07237 | CHEMBL5422 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 2.946E-06 | 6.414E-02 | PPARA, PPARD |
| BP | GO:0009987; cellular process | GO:0009755; hormone-mediated signaling pathway | 6.267E-06 | 6.823E-02 | PPARA, PPARD, TSHR |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 2.336E-05 | 9.543E-02 | P4HB, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:1901652; response to peptide | 5.693E-05 | 1.242E-01 | AKR1B1, PPARA, TSHR |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 6.274E-05 | 1.242E-01 | PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 9.118E-05 | 1.542E-01 | PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 5.177E-04 | 2.336E-01 | TSHR |
| MF | Unclassified; | GO:0032403; protein complex binding | 6.526E-04 | 2.681E-01 | P4HB, PPARA, TSHR |
| MF | GO:0005488; binding | GO:0044877; macromolecular complex binding | 1.242E-03 | 3.352E-01 | P4HB, PPARA, TSHR |
| MF | GO:0005488; binding | GO:0051525; NFAT protein binding | 1.294E-03 | 3.352E-01 | PPARA |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 4.723E-02 | 1.000E+00 | TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.165E-04 | 2.330E-03 | PPARA, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 9.658E-04 | 9.658E-03 | PPARA, TSHR |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 8.969E-03 | 3.205E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 7.478E-03 | 3.205E-02 | AKR1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.417E-02 | 3.205E-02 | PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.392E-02 | 3.205E-02 | TSHR |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.318E-02 | 3.205E-02 | TSHR |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 7.975E-03 | 3.205E-02 | AKR1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 1.466E-02 | 3.205E-02 | AKR1B1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.763E-02 | 3.205E-02 | TSHR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
