CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	P4HB; AKR1B1;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.946E-06	6.414E-02	PPARA, PPARD
BP	GO:0009987; cellular process	GO:0009755; hormone-mediated signaling pathway	6.267E-06	6.823E-02	PPARA, PPARD, TSHR
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	2.336E-05	9.543E-02	P4HB, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:1901652; response to peptide	5.693E-05	1.242E-01	AKR1B1, PPARA, TSHR
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	4.723E-02	1.000E+00	TSHR
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	6.274E-05	1.242E-01	PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	9.118E-05	1.542E-01	PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	5.177E-04	2.336E-01	TSHR
MF	Unclassified;	GO:0032403; protein complex binding	6.526E-04	2.681E-01	P4HB, PPARA, TSHR
MF	GO:0005488; binding	GO:0044877; macromolecular complex binding	1.242E-03	3.352E-01	P4HB, PPARA, TSHR

Showing 1 to 10 of 11 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	8.969E-03	3.205E-02	AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	7.478E-03	3.205E-02	AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7.975E-03	3.205E-02	AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.466E-02	3.205E-02	AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	9.658E-04	9.658E-03	PPARA, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.165E-04	2.330E-03	PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.392E-02	3.205E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.763E-02	3.205E-02	TSHR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.417E-02	3.205E-02	PPARD
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	1.318E-02	3.205E-02	TSHR

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Dorycnium hirsutum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities