CMAUP Plant Collective Molecular Activities

Plant Name: Liriope muscari

Taxonomic Information:

Plant ID: NPO5275
Plant Latin Name: Liriope muscari
Taxonomy Genus: Liriope
Taxonomy Family: Asparagaceae

Plant External Links:

NCBI TaxonomyDB: 39529
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM

Medicinal Functions:

Antiinflammatory; Aphrodisiac; Pectoral; Stimulant; Tonic

Geographical Distribution:

South Korea; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.490E-06	5.352E-02	SLCO1B1, SLCO1B3, TSHR
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	4.916E-06	5.352E-02	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	1.214E-05	6.081E-02	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	1.396E-05	6.081E-02	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	8.864E-06	6.081E-02	SLCO1B1, SLCO1B3
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	4.141E-04	5.010E-01	TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	4.141E-04	5.010E-01	TSHR
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	1.465E-03	1.000E+00	SLCO1B1, SLCO1B3, TSHR
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	3.333E-02	1.000E+00	LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	7.421E-05	7.421E-04	SLCO1B1, SLCO1B3
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	1.056E-02	2.554E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.115E-02	2.554E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.413E-02	2.554E-02	TSHR
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.472E-02	2.554E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.650E-02	2.554E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.788E-02	2.554E-02	LMNA
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.771E-02	3.464E-02	LMNA
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	3.921E-02	4.357E-02	TSHR
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.426E-02	5.426E-02	TSHR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases