CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Unclassified	LMNA; HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.946E-06	6.414E-02	PPARA, PPARD
BP	GO:0009987; cellular process	GO:0009755; hormone-mediated signaling pathway	6.267E-06	6.823E-02	PPARA, PPARD, TSHR
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	2.336E-05	8.837E-02	LMNA, PPARA, PPARD
BP	GO:0009987; cellular process	GO:0060548; negative regulation of cell death	2.841E-05	8.837E-02	HTT, LMNA, PPARA, PPARD
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.177E-04	2.136E-01	PPARA, PPARD
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	1.284E-04	2.151E-01	HTT, LMNA, PPARA, PPARD, TSHR
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	2.607E-03	5.620E-01	HTT, LMNA, PPARA, PPARD
CC	GO:0044464; cell part	GO:0005770; late endosome	3.446E-02	1.000E+00	HTT
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	4.149E-02	1.000E+00	LMNA
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	4.723E-02	1.000E+00	TSHR

Showing 1 to 10 of 15 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	9.658E-04	9.175E-03	PPARA, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.165E-04	2.214E-03	PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.392E-02	4.237E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.763E-02	4.237E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	1.738E-02	4.237E-02	PPARA
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.417E-02	4.237E-02	PPARD
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	1.318E-02	4.237E-02	TSHR
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.837E-02	4.237E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	2.230E-02	4.237E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	2.058E-02	4.237E-02	LMNA

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Typha angustata

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities