Plant Name: Typha angustata
Taxonomic Information:
Plant ID: NPO5243
Plant Latin Name: Typha angustata
Taxonomy Genus: Typha
Taxonomy Family: Typhaceae
Plant External Links:
NCBI TaxonomyDB:
453243
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
China; IndiaTraditional Medicine System:
Sowa-Rigpa; TCM; Unani; AyurvedaGeographical Distribution:
India; China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| PPARA; PPARD; | |
| LMNA; HTT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 2.946E-06 | 6.414E-02 | PPARA, PPARD |
| BP | GO:0009987; cellular process | GO:0009755; hormone-mediated signaling pathway | 6.267E-06 | 6.823E-02 | PPARA, PPARD, TSHR |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 2.336E-05 | 8.837E-02 | LMNA, PPARA, PPARD |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 2.841E-05 | 8.837E-02 | HTT, LMNA, PPARA, PPARD |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 6.274E-05 | 1.366E-01 | PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 9.118E-05 | 1.805E-01 | PPARA, PPARD |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 1.177E-04 | 2.136E-01 | PPARA, PPARD |
| BP | GO:0032502; developmental process | GO:0048856; anatomical structure development | 1.284E-04 | 2.151E-01 | HTT, LMNA, PPARA, PPARD, TSHR |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 5.177E-04 | 2.890E-01 | TSHR |
| MF | GO:0005488; binding | GO:0051525; NFAT protein binding | 1.294E-03 | 4.317E-01 | PPARA |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 1.811E-03 | 4.929E-01 | PPARA |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 2.607E-03 | 5.620E-01 | HTT, LMNA, PPARA, PPARD |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 3.446E-02 | 1.000E+00 | HTT |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.149E-02 | 1.000E+00 | LMNA |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 4.723E-02 | 1.000E+00 | TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.165E-04 | 2.214E-03 | PPARA, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 9.658E-04 | 9.175E-03 | PPARA, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.417E-02 | 4.237E-02 | PPARD |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.318E-02 | 4.237E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.392E-02 | 4.237E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.763E-02 | 4.237E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.738E-02 | 4.237E-02 | PPARA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.837E-02 | 4.237E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 2.230E-02 | 4.237E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 2.058E-02 | 4.237E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
