CMAUP Plant Collective Molecular Activities

Plant Name: Lawsonia inermis

Taxonomic Information:

Plant ID: NPO5227
Plant Latin Name: Lawsonia inermis
Taxonomy Genus: Lawsonia
Taxonomy Family: Lythraceae

Plant External Links:

NCBI TaxonomyDB: 141191
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Pakistan; Italy; India; Tanzania; Indonesia; Lebanon; Rwanda; Jordan; China; Thailand; Kenya; Nigeria; Iraq

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM

Geographical Distribution:

Pakistan; Italy; Lebanon; Tanzania; Indonesia; India; Rwanda; Jordan; Kenya; China; Nigeria; Iraq; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	BLM; ALOX12; HSD17B10; IDO1; NOX4; AOX1; POLB;
Protein Kinase	AXL; MET; FLT3; CDK1; MAPK1; EGFR; PIM1; MAP2K1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Metallo protease	MMP12;
Transcription Factor	HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	IDO1	Indoleamine 2,3-dioxygenase	P14902	CHEMBL4685
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	CHEMBL3587
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.506E-09	9.409E-06	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	1.025E-07	5.193E-05	BLM, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, MAPK1, NOX4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.000E-07	1.423E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.407E-07	1.869E-04	CYP1A1, CYP1B1, CYP2C9
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	5.929E-07	2.017E-04	ALOX12, EGFR, HIF1A, IGF1R, KDR, MAPK1, MET, NOX4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.328E-07	2.120E-04	BLM, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP12
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.130E-07	2.761E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.001E-06	2.894E-04	CYP1A1, CYP1B1, CYP2C9, NOX4
MF	GO:0005488; binding	GO:0020037; heme binding	2.416E-06	5.368E-04	CYP1A1, CYP1B1, CYP2C9, IDO1, NOX4
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	2.830E-06	6.042E-04	ESR1, ESR2
MF	GO:0005488; binding	GO:0005524; ATP binding	2.980E-06	6.295E-04	AURKB, AXL, BLM, CDK1, EGFR, FLT3, IGF1R, KDR, MAP2K1, MAPK1, MET, PIM1
BP	GO:0065007; biological regulation	GO:0043406; positive regulation of MAP kinase activity	5.003E-06	9.155E-04	CDK1, EGFR, FLT3, MAP2K1, MAPK1, NOX4
BP	GO:0022414; reproductive process	GO:0001892; embryonic placenta development	5.077E-06	9.167E-04	EGFR, ESRRB, HIF1A
MF	Unclassified;	GO:0004872; receptor activity	5.094E-06	9.167E-04	AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NPSR1, TSHR
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.917E-06	1.039E-03	CYP1A1, CYP1B1, CYP2C9
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	7.207E-06	1.207E-03	CDK1, ESR1, ESR2, ESRRA, ESRRB
MF	GO:0005488; binding	GO:0005506; iron ion binding	7.207E-06	1.207E-03	ALOX12, AOX1, CYP1A1, CYP1B1, CYP2C9
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	8.303E-06	1.380E-03	AXL, CDK1, EGFR, FLT3
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	8.482E-06	1.399E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.114E-05	1.732E-03	ESR1, ESR2, ESRRA, ESRRB, PIM1
BP	GO:0008152; metabolic process	GO:0045893; positive regulation of transcription, DNA-templated	1.345E-05	1.971E-03	BLM, EGFR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, MAP2K1, MAPK1, MET, MMP12
MF	GO:0005488; binding	GO:0005496; steroid binding	1.358E-05	1.971E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0009987; cellular process	GO:0090170; regulation of Golgi inheritance	1.695E-05	2.290E-03	MAP2K1, MAPK1
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	1.695E-05	2.290E-03	ESR1, ESR2
BP	GO:0009987; cellular process	GO:0014066; regulation of phosphatidylinositol 3-kinase signaling	2.187E-05	2.768E-03	EGFR, FLT3, KDR, MAPK1
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	2.219E-05	2.776E-03	AXL, CA2, CYP1A1, EGFR, ESR1, ESRRA, FLT3, IDO1
BP	GO:0008152; metabolic process	GO:1903580; positive regulation of ATP metabolic process	2.622E-05	3.070E-03	CDK1, ESRRB, HIF1A
BP	GO:0032501; multicellular organismal process	GO:0060440; trachea formation	4.228E-05	4.513E-03	MAP2K1, MAPK1
BP	GO:0065007; biological regulation	GO:0048872; homeostasis of number of cells	4.417E-05	4.646E-03	AXL, FLT3, HIF1A, POLB
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	4.885E-05	5.041E-03	BLM, EGFR, IGF1R, MAPK1, NOX4, TSHR
BP	GO:0009987; cellular process	GO:0001961; positive regulation of cytokine-mediated signaling pathway	5.351E-05	5.420E-03	AXL, HIF1A, MMP12
BP	GO:0032501; multicellular organismal process	GO:0007435; salivary gland morphogenesis	5.912E-05	5.749E-03	EGFR, POLB
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	5.912E-05	5.749E-03	FLT3, KDR
MF	GO:0098772; molecular function regulator	GO:0030235; nitric-oxide synthase regulator activity	5.912E-05	5.749E-03	EGFR, ESR1
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	6.890E-05	6.580E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	6.998E-05	6.597E-03	EGFR, IGF1R, KDR
BP	GO:0050896; response to stimulus	GO:0009314; response to radiation	7.048E-05	6.611E-03	AURKB, BLM, EGFR, HIF1A, NOX4, POLB
BP	GO:0032501; multicellular organismal process	GO:0060020; Bergmann glial cell differentiation	7.874E-05	7.174E-03	MAP2K1, MAPK1
BP	GO:0050896; response to stimulus	GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA	7.874E-05	7.174E-03	EGFR, MAP2K1
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	1.004E-04	8.887E-03	AURKB, CDK1, POLB
MF	Unclassified;	GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity	1.011E-04	8.916E-03	EGFR, KDR
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.040E-04	9.069E-03	ALOX12, AOX1, CYP1A1, CYP1B1, CYP2C9, HSD17B10, IDO1, NOX4
BP	GO:0032502; developmental process	GO:0002009; morphogenesis of an epithelium	1.087E-04	9.428E-03	CA2, EGFR, ESR1, HIF1A, MET
BP	GO:0008152; metabolic process	GO:0045740; positive regulation of DNA replication	1.122E-04	9.655E-03	CDK1, EGFR, IGF1R

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.096E-09	7.710E-08	MAP2K1, KDR, MAPK1, HIF1A, ESR1, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.159E-09	7.710E-08	MAP2K1, FLT3, MAPK1, MET, HIF1A, EGFR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.073E-07	3.569E-06	MAP2K1, MAPK1, MET, EGFR, IGF1R
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.382E-07	1.265E-05	CYP1A1, AOX1, CYP1B1, IDO1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	5.707E-07	1.265E-05	MAP2K1, MAPK1, ESR1, EGFR, ESR2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	8.696E-07	1.446E-05	MAP2K1, KDR, MAPK1, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.121E-06	1.657E-05	MAP2K1, KDR, MAPK1, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	6.952E-07	1.321E-05	MAP2K1, MAPK1, HIF1A, EGFR, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.439E-08	6.381E-07	CA12, CA2, CA4, CA7
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.715E-06	2.281E-05	MAP2K1, KDR, MAPK1, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.151E-06	3.493E-05	MAP2K1, FLT3, MAPK1, HIF1A, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.281E-06	2.757E-05	MAP2K1, FLT3, PIM1, MAPK1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	3.873E-06	3.912E-05	MAP2K1, MAPK1, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	5.837E-06	5.176E-05	MAP2K1, MAPK1, ESR1, ESR2
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	4.118E-06	3.912E-05	MAP2K1, MAPK1, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	8.058E-06	6.304E-05	MAP2K1, PIM1, CYP1B1, MAPK1, MET, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.765E-05	1.118E-04	MAP2K1, KDR, MAPK1, MET, EGFR, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	6.513E-06	5.414E-05	MAPK1, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.358E-05	9.033E-05	MAP2K1, MAPK1, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.989E-05	1.202E-04	MAP2K1, CDK1, MAPK1, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	1.299E-05	9.033E-05	MAP2K1, CDK1, MAPK1, EGFR
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	2.240E-05	1.295E-04	MAP2K1, MAPK1, HIF1A, EGFR
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.364E-05	1.864E-04	CYP2C9, MAP2K1, MAPK1, ALOX12
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	4.128E-05	2.138E-04	MAP2K1, MAPK1, ESR1, HIF1A
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	4.855E-05	2.392E-04	MAP2K1, CDK1, MAPK1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	6.585E-05	3.128E-04	MAP2K1, MAPK1, EGFR, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8.493E-05	3.672E-04	MAP2K1, ESRRB, MAPK1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	1.069E-04	4.442E-04	MAP2K1, MAPK1, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	7.608E-05	3.489E-04	CYP1A1, CYP1B1, IGF1R
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	8.368E-04	2.650E-03	KDR, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	8.560E-05	3.672E-04	MAP2K1, MAPK1, EGFR
Unclassified	Unclassified	hsa04320	Dorso-ventral axis formation	1.165E-05	8.609E-05	MAP2K1, MAPK1, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	1.380E-04	5.398E-04	MAP2K1, KDR, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	1.314E-04	5.294E-04	MAP2K1, MAPK1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	4.180E-05	2.138E-04	MAP2K1, MAPK1, EGFR
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.745E-04	6.446E-04	MAP2K1, MAPK1, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	4.504E-04	1.497E-03	MAP2K1, MAPK1, EGFR
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9.112E-04	2.818E-03	FLT3, KDR, MET, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	3.947E-04	1.346E-03	MAP2K1, MAPK1, EGFR
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.667E-04	6.336E-04	CYP2C9, CYP1A1, AOX1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.353E-04	8.457E-04	CYP2C9, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04072	Phospholipase D signaling pathway	1.702E-03	4.922E-03	MAP2K1, MAPK1, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04921	Oxytocin signaling pathway	2.218E-03	6.276E-03	MAP2K1, MAPK1, EGFR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.316E-04	1.161E-03	CYP2C9, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	3.207E-03	8.705E-03	FLT3, MET, IGF1R
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2.840E-03	7.869E-03	AOX1, HSD17B10
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05020	Prion diseases	1.518E-03	4.487E-03	MAP2K1, MAPK1
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.042E-03	3.151E-03	MAP2K1, MAPK1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6.536E-04	2.120E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; NPSR1;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
NA: NA	Edema	NA	CA2;
H00-H59: Diseases of the eye and adnexa	Choroidal neovascularisation	H35	ESRRA;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	ESRRA;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; EGFR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; EGFR;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1; FLT3;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; IGF1R;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR;
C00-D49: Neoplasms	Melanoma	C43	KDR; EGFR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1; CDK1; IGF1R;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	IDO1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ESRRA;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; EGFR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	IDO1; ESR1; PIM1; MET; CDK1; IGF1R; KDR; FLT3; HIF1A; MAPK1; EGFR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	ESRRA;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	ESRRA; EGFR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1; ESRRA;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; EGFR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR; EGFR;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
NA: NA	GIST	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; EGFR;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; CDK1; IGF1R; KDR; FLT3; EGFR;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1; EGFR;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MAPK1; EGFR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	ESRRA;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ESRRA;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	ESRRA;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; ESRRA;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ESRRA;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
NA: NA	Menopausal disorder	NA	ESR1;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; EGFR;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ESRRA;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; EGFR;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; FLT3; EGFR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
NA: NA	Postmenopausal disorder	NA	ESR1;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases