Plant Name: Catha edulis
Taxonomic Information:
Plant ID: NPO5194
Plant Latin Name: Catha edulis
Taxonomy Genus: Catha
Taxonomy Family: Celastraceae
Plant External Links:
NCBI TaxonomyDB:
123405
Plant-of-the-World-Online:
941530-1
Used in Medicines:
Country/Region:
Madagascar; Angola; South Africa; Tanzania; Zimbabwe; Rwanda; Swaziland; KenyaTraditional Medicine System:
Geographical Distribution:
Eritrea; Madagascar; Angola; Uganda; South Africa; Sudan; Tanzania; Zimbabwe; Zambia; United States; Ethiopia; Rwanda; Mozambique; Somalia; Swaziland; Kenya; Yemen; Malawi
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TRPA1; | |
| HIF1A; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 8.583E-05 | 5.202E-01 | HIF1A, LMNA |
| BP | GO:0050896; response to stimulus | GO:0009628; response to abiotic stimulus | 1.409E-04 | 5.202E-01 | HIF1A, LMNA, TRPA1 |
| BP | GO:0009987; cellular process | GO:2001234; negative regulation of apoptotic signaling pathway | 3.537E-04 | 5.202E-01 | HIF1A, LMNA |
| CC | GO:0044464; cell part | GO:0032421; stereocilium bundle | 7.764E-04 | 5.635E-01 | TRPA1 |
| CC | GO:0043226; organelle | GO:0016607; nuclear speck | 1.078E-03 | 5.879E-01 | HIF1A, LMNA |
| MF | GO:0005215; transporter activity | GO:0015278; calcium-release channel activity | 2.793E-03 | 6.829E-01 | TRPA1 |
| MF | GO:0005488; binding | GO:0035035; histone acetyltransferase binding | 4.188E-03 | 7.330E-01 | HIF1A |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 4.962E-03 | 7.718E-01 | HIF1A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 8.973E-03 | 2.220E-02 | HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 9.868E-03 | 2.220E-02 | HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.002E-02 | 2.220E-02 | HIF1A |
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.463E-02 | 2.220E-02 | TRPA1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.106E-02 | 2.220E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.240E-02 | 2.220E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.344E-02 | 2.220E-02 | LMNA |
| 09160 Human Diseases | 09161 Cancers | hsa05231 | Choline metabolism in cancer | 1.507E-02 | 2.220E-02 | HIF1A |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 1.537E-02 | 2.220E-02 | HIF1A |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.760E-02 | 2.288E-02 | HIF1A |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
