Plant Name: Myristica malabarica
Taxonomic Information:
Plant ID: NPO5137
Plant Latin Name: Myristica malabarica
Taxonomy Genus: Myristica
Taxonomy Family: Myristicaceae
Plant External Links:
NCBI TaxonomyDB:
741156
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
China; IndiaTraditional Medicine System:
Indian Folk; TCM; Ayurveda; SiddhaGeographical Distribution:
India; China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| PTPN1; PTPN2; ACP1; PTPRF; | |
| RECQL; HSD11B1; AKR1B10; | |
| PRKCA; | |
| CA1; CA12; CA5B; CA5A; CA6; | |
| RORC; | |
| NR1H4; | |
| ALDH2; | |
| MMP12; MMP2; | |
| HTT; RAB9A; LMNA; NPC1; | |
| L3MBTL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Oxidoreductase | ALDH2 | Aldehyde dehydrogenase | P05091 | CHEMBL1935 |
| Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
| Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.072E-11 | 1.167E-07 | CA1, CA12, CA5A, CA5B, CA6 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.768E-10 | 2.009E-06 | CA1, CA12, CA5A, CA5B, CA6, L3MBTL1, MMP12, MMP2, NR1H4, PRKCA, PTPN1, RORC |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.319E-09 | 7.183E-06 | CA1, CA12, CA5A, CA5B, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.772E-09 | 1.643E-05 | CA1, CA12, CA5A, CA5B, CA6 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 3.666E-08 | 1.141E-04 | AKR1B10, CYP1A2, CYP2C9, CYP2D6, HSD11B1, NPC1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 4.857E-08 | 1.322E-04 | CYP1A2, CYP2C9, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 5.313E-07 | 1.157E-03 | CYP1A2, CYP2C9, CYP2D6 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 5.640E-06 | 8.187E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 5.640E-06 | 8.187E-03 | GPBAR1, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 1.127E-05 | 1.275E-02 | CYP1A2, CYP2C9 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 3.323E-05 | 2.783E-02 | CYP1A2, CYP2C9, CYP2D6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.854E-11 | 1.854E-09 | CA12, CA1, CA5B, CA5A, CA6 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.690E-06 | 1.345E-04 | HSD11B1, CYP2C9, CYP2D6, CYP1A2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.083E-04 | 3.336E-03 | CYP2C9, CYP2D6, CYP1A2 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.334E-04 | 3.336E-03 | PTPN1, ACP1, PTPRF |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.810E-04 | 3.619E-03 | HSD11B1, CYP2C9, CYP1A2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 4.534E-04 | 7.556E-03 | CYP2C9, CYP2D6, PRKCA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 1.326E-03 | 1.474E-02 | ALDH2, CYP1A2 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.075E-03 | 1.344E-02 | AKR1B10, ALDH2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 6.967E-04 | 9.953E-03 | CYP2C9, CYP1A2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 2.864E-03 | 2.603E-02 | AKR1B10, ALDH2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | ALDH2; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Substance dependence | F10-F19 | ALDH2; |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ALDH2; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6; |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
