CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	GLA; PLA2G1B; TDP1; AKR1B10; ALOX15; POLB;
Lyase	CA2; CA1; CA12; CA9; CA3; CA14; CA7; CA5A; CA6;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Cysteine protease	CASP1; CASP7;
Transcription Factor	TP53; HIF1A; NFKB1;
Unclassified	HTT;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.523E-06	5.073E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	6.523E-06	5.073E-03	GPBAR1, NR1H4
BP	GO:0065007; biological regulation	GO:0050790; regulation of catalytic activity	1.006E-05	7.301E-03	CASP1, CASP7, CDC25B, GLA, HIF1A, HTT, NFKB1, PLA2G1B, PTPN1, PTPN2, TP53, TSHR, XDH
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.303E-05	8.601E-03	PTPN1, PTPN2
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.674E-18	5.719E-14	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.634E-16	1.147E-12	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
CC	GO:0044464; cell part	GO:0005829; cytosol	1.237E-04	3.499E-02	AKR1B10, ALOX15, CA1, CA2, CA3, CA7, CASP1, CASP7, CDC25B, HIF1A, HTT, NFKB1, PLA2G1B, PTPN1, PTPN2, TP53, XDH
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.185E-08	2.346E-05	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, NR1H4, PTPN1, TP53
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	6.523E-06	5.073E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.841E-23	1.054E-18	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.716E-22	1.871E-20	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.765E-06	5.322E-04	PLA2G1B, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.787E-05	2.667E-03	PLA2G1B, ALOX15, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	8.611E-04	1.564E-02	AKR1B10, GLA
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	3.300E-03	3.270E-02	AKR1B10, GLA
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.074E-03	1.672E-02	CASP7, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	6.835E-05	2.483E-03	CASP7, CASP1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.725E-04	3.761E-03	CASP7, CASP1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	3.186E-03	3.270E-02	POLB, TP53, NFKB1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	2.477E-03	3.270E-02	CASP1, TP53

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; TP53; CDC25B;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Agathosma scaberula

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities