CMAUP Plant Collective Molecular Activities

Plant Name: Cycas revoluta

Taxonomic Information:

Plant ID: NPO5082
Plant Latin Name: Cycas revoluta
Taxonomy Genus: Cycas
Taxonomy Family: Cycadaceae

Plant External Links:

NCBI TaxonomyDB: 3396
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; Indonesia; India

Traditional Medicine System:

Indian Folk; TCM; Siddha

Medicinal Functions:

Astringent; Cancer; Diuretic; Emmenagogue; Expectorant; Tonic

Geographical Distribution:

India; Indonesia; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1; OPRD1;
Protein Kinase	AXL; CDK1; IGF1R; FLT3; AURKB; MET; PIM1; KDR;
Lyase	CA7; CA4; CA12;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALOX12; HSD17B10; NOX4; POLB;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.285E-07	6.665E-04	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.082E-06	1.159E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.137E-06	1.159E-03	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.400E-06	1.220E-03	AURKB, FLT3, IGF1R, KDR, PIM1
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	6.024E-06	4.099E-03	ALOX12, CA12, CA4, CA7, CYP1B1, CYP3A4, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.631E-06	4.376E-03	CA12, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.224E-05	7.201E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.310E-05	7.436E-03	CYP1B1, CYP3A4, NOX4
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	1.572E-05	8.349E-03	AXL, CYP1B1, FLT3, IGF1R, KDR, NOX4, NR1H4, OPRD1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.763E-07	3.631E-05	CA12, CA4, CA7
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.034E-03	9.677E-03	KDR, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.019E-03	9.677E-03	KDR, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.131E-03	9.677E-03	CYP1B1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	7.301E-04	9.677E-03	FLT3, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.156E-03	9.677E-03	KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.426E-03	9.677E-03	KDR, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.467E-03	9.677E-03	FLT3, PIM1
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	2.079E-03	9.677E-03	KDR, MET, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	2.219E-03	9.677E-03	FLT3, KDR, MET
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.020E-03	9.677E-03	FLT3, MET
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.519E-03	9.677E-03	CYP1B1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	2.265E-03	9.677E-03	MET, IGF1R
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.265E-03	9.677E-03	NR1H4, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.458E-03	9.677E-03	MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.393E-03	9.677E-03	CYP1B1, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; OPRD1;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; OPRD1;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
NA: NA	Acute nonspecific diarrhea	NA	OPRD1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases