CMAUP Plant Collective Molecular Activities

Plant Name: Aegle marmelos

Taxonomic Information:

Plant ID: NPO5045
Plant Latin Name: Aegle marmelos
Taxonomy Genus: Aegle
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 68527
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Sri Lanka; Thailand; Indonesia; India; China

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; Homeopathy

Geographical Distribution:

Sri Lanka; India; Indonesia; China; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA12; CA9;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.629E-07	1.226E-02	CA12, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.377E-06	3.677E-02	CA12, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.071E-06	3.681E-02	CA12, CA9
BP	GO:0009987; cellular process	GO:0043618; regulation of transcription from RNA polymerase II promoter in response to stress	1.156E-02	1.000E+00	CA9
BP	GO:0032502; developmental process	GO:0002009; morphogenesis of an epithelium	2.899E-02	1.000E+00	CA9
BP	GO:0051179; localization	GO:0006810; transport	4.461E-02	1.000E+00	CA12, CA9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.917E-02	1.000E+00	CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.769E-03	1.000E+00	CA12, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.800E-07	6.800E-07	CA12, CA9

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases