Plant ID: NPO503
Plant Latin Name: Trigonostemon lii
Taxonomy Genus: Trigonostemon
Taxonomy Family: Euphorbiaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
HTT; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 3.996E-10 | 8.701E-06 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.427E-09 | 2.933E-05 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 5.894E-09 | 2.933E-05 | CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 5.894E-09 | 2.933E-05 | CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 4.718E-08 | 1.468E-04 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 1.930E-07 | 4.202E-04 | CYP1A1, CYP1A2 |
BP | GO:0008152; metabolic process | GO:0050665; hydrogen peroxide biosynthetic process | 9.002E-07 | 1.089E-03 | CYP1A1, CYP1A2 |
MF | GO:0005488; binding | GO:0020037; heme binding | 1.131E-06 | 1.232E-03 | CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 2.218E-06 | 2.012E-03 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0009987; cellular process | GO:0071280; cellular response to copper ion | 2.507E-06 | 2.183E-03 | CYP1A1, CYP1A2 |
BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 8.185E-06 | 6.855E-03 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0050896; response to stimulus | GO:0035902; response to immobilization stress | 8.864E-06 | 7.148E-03 | CYP1A1, CYP1A2 |
MF | GO:0003824; catalytic activity | GO:0032451; demethylase activity | 2.377E-05 | 1.618E-02 | CYP1A1, CYP1A2 |
CC | GO:0016020; membrane | GO:0031090; organelle membrane | 3.901E-04 | 1.592E-01 | CYP1A1, CYP1A2, CYP1B1, HTT |
CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 4.168E-04 | 1.592E-01 | CYP1A1, CYP1A2, CYP1B1 |
CC | GO:0044464; cell part | GO:0005739; mitochondrion | 2.450E-02 | 1.000E+00 | CYP1A1, CYP1B1 |
CC | GO:0044464; cell part | GO:0005770; late endosome | 2.767E-02 | 1.000E+00 | HTT |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 2.960E-08 | 3.552E-07 | CYP1A2, CYP1A1, CYP1B1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 9.239E-08 | 5.543E-07 | CYP1A2, CYP1A1, CYP1B1 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.861E-07 | 7.445E-07 | CYP1A2, CYP1A1, CYP1B1 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 2.649E-07 | 7.948E-07 | CYP1A2, CYP1A1, CYP1B1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 3.663E-05 | 8.792E-05 | CYP1A1, CYP1B1 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 6.214E-05 | 1.243E-04 | CYP1A2, CYP1A1 |
Unclassified | Unclassified | hsa01100 | Metabolic pathways | 2.116E-02 | 2.539E-02 | CYP1A2, CYP1A1 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.373E-02 | 1.831E-02 | CYP1A2 |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.788E-03 | 8.682E-03 | CYP1A2 |
09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 9.997E-04 | 1.714E-03 | CYP1A2 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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