Plant Name: Pachysandra procumbens
Taxonomic Information:
Plant ID: NPO4994
Plant Latin Name: Pachysandra procumbens
Taxonomy Genus: Pachysandra
Taxonomy Family: Buxaceae
Plant External Links:
NCBI TaxonomyDB:
83909
Plant-of-the-World-Online:
353207-1
Used in Medicines:
Unknown.
Geographical Distribution:
United States
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Hydrolase | BCHE | Butyrylcholinesterase | P06276 | CHEMBL1914 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 5.361E-09 | 1.167E-04 | ACHE, BCHE |
| MF | GO:0005488; binding | GO:0001540; amyloid-beta binding | 9.488E-06 | 4.706E-02 | ACHE, BCHE |
| BP | GO:0008152; metabolic process | GO:0042133; neurotransmitter metabolic process | 2.052E-05 | 6.383E-02 | ACHE, BCHE |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 8.282E-04 | 6.011E-01 | BCHE |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 1.107E-02 | 1.107E-02 | ACHE |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 9.478E-03 | 1.107E-02 | ACHE |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
