CMAUP Plant Collective Molecular Activities

Plant Name: Lophozonia menziesii

Plant ID: NPO490
Plant Latin Name: Lophozonia menziesii
Taxonomy Genus: Lophozonia
Taxonomy Family: Nothofagaceae

NCBI TaxonomyDB: 28945
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1;
Hydrolase	ACHE;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Toll-like and Il-1 receptors	TLR2;
Unclassified	MAPT;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4;

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.752E-07	7.351E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.687E-06	1.225E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	2.362E-06	1.286E-02	CYP1A2, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	7.417E-06	2.019E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	7.417E-06	2.019E-02	CYP1A2, CYP3A4
BP	GO:0002376; immune system process	GO:0001774; microglial cell activation	1.527E-05	3.695E-02	MAPT, TLR2
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.838E-05	5.617E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	3.644E-05	5.667E-02	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.106E-04	1.417E-01	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0044877; macromolecular complex binding	2.119E-04	2.255E-01	ACHE, MAPT, PPARA, TLR2
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	1.759E-03	3.618E-01	ACHE, CYP1A2, CYP3A4, MAPT, PPARA, TDP1, TLR2
CC	Unclassified;	GO:0106003; amyloid-beta complex	3.980E-03	4.952E-01	TLR2
CC	GO:0044464; cell part	GO:0030673; axolemma	5.785E-03	5.942E-01	MAPT

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases